PMID- 10371383
OWN - NLM
STAT- MEDLINE
DCOM- 19990913
LR  - 20190910
IS  - 0887-8994 (Print)
IS  - 0887-8994 (Linking)
VI  - 20
IP  - 5
DP  - 1999 May
TI  - Periventricular leukomalacia: relation to gestational age and axonal injury.
PG  - 370-4
AB  - Eighty-five infants ranging from 22 to 41 weeks gestation were diagnosed as 
      having periventricular leukomalacia (PVL) using traditional neuropathologic 
      methods. The lesions were also studied by immunocytochemistry for beta-amyloid 
      precursor protein (beta-APP), a glycoprotein that has been observed in PVL. Using 
      this technique, the distribution of white matter tissue necrosis was defined as 
      focal, widespread, and diffuse. The type of PVL correlated with the gestational 
      age at birth. The youngest infants tended to demonstrate widespread necrosis, and 
      the oldest infants exhibited more focal necrosis. beta-APP immunopositivity was 
      present in the axons around the foci of white matter necrosis in 76% of the 
      patients and in the neurons of the adjacent cortex in 66% of the patients. In 
      age-matched control patients, there was no beta-APP reactivity in the cerebral 
      white matter or the cortex. In most patients the distribution of 
      beta-APP-positive axons proved to be a useful marker for demonstrating the type 
      of PVL; however, the relationship of beta-APP to the pathogenesis of PVL requires 
      further study.
FAU - Deguchi, K
AU  - Deguchi K
AD  - Department of Mental Retardation and Birth Defect Research, National Institute of 
      Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
FAU - Oguchi, K
AU  - Oguchi K
FAU - Matsuura, N
AU  - Matsuura N
FAU - Armstrong, D D
AU  - Armstrong DD
FAU - Takashima, S
AU  - Takashima S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatr Neurol
JT  - Pediatric neurology
JID - 8508183
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Amyloid beta-Protein Precursor/*analysis
MH  - Axons/chemistry
MH  - Biomarkers
MH  - Brain/*pathology
MH  - Case-Control Studies
MH  - Cerebral Cortex/pathology
MH  - Chi-Square Distribution
MH  - Disease Progression
MH  - *Gestational Age
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Leukomalacia, Periventricular/classification/etiology/*pathology
MH  - Necrosis
MH  - Nerve Degeneration/pathology
MH  - Neural Pathways/pathology
EDAT- 1999/06/17 00:00
MHDA- 1999/06/17 00:01
CRDT- 1999/06/17 00:00
PHST- 1999/06/17 00:00 [pubmed]
PHST- 1999/06/17 00:01 [medline]
PHST- 1999/06/17 00:00 [entrez]
AID - S0887899499000107 [pii]
AID - 10.1016/s0887-8994(99)00010-7 [doi]
PST - ppublish
SO  - Pediatr Neurol. 1999 May;20(5):370-4. doi: 10.1016/s0887-8994(99)00010-7.