PMID- 10372135
OWN - NLM
STAT- MEDLINE
DCOM- 19990712
LR  - 20190616
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 872
DP  - 1999 Apr 30
TI  - The Placental/Umbilical Cord Blood Program of the New York Blood Center. A 
      progress report.
PG  - 328-34; discussion 334-5
AB  - The transplantation of placental/umbilical cord blood (P/CB) has been used 
      successfully to reconstitute bone marrow function in both related and unrelated 
      recipients. We report here the experience of the New York Blood Center P/CB 
      Program. Since its inception in 1992, over 400 unrelated transplants were 
      supported between July 1993 and September 1997. Overall, event-free survival for 
      all diagnoses and ages approached 0.45. Success and rapidity of engraftment 
      correlated most strongly with the degree of human leukocyte antigen (HLA) 
      disparity and cell dose/kg body weight recipient. Acute graft-versus-host disease 
      (GVHD) was common in all patients but, surprisingly, did not differ between those 
      patients who received grafts having one or more antigen mismatches. Chronic GVHD 
      was uncommon and only rarely contributed to death. These results demonstrate the 
      feasibility of large-scale P/CB banking for the provision of cryopreserved stem 
      cell preparations for unrelated transplants. The degree of the program's success 
      argues strongly for additional P/CB banks in order to increase the likelihood of 
      finding a suitable stem cell preparation for patients for whom related matched 
      donors do not exist.
FAU - Rubinstein, P
AU  - Rubinstein P
AD  - Lindsley F. Kimball Research Institute of the New York Blood Center, New York, 
      New York 10021, USA.
FAU - Adamson, J W
AU  - Adamson JW
FAU - Stevens, C
AU  - Stevens C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
SB  - IM
MH  - Anemia/therapy
MH  - Blood Banks/*organization & administration/statistics & numerical data
MH  - Blood Preservation
MH  - Cryopreservation
MH  - Fetal Blood/*cytology
MH  - Graft vs Host Disease/epidemiology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Testing
MH  - Humans
MH  - Infant, Newborn
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/therapy
MH  - New York City
MH  - Placenta
EDAT- 1999/06/18 00:00
MHDA- 1999/06/18 00:01
CRDT- 1999/06/18 00:00
PHST- 1999/06/18 00:00 [pubmed]
PHST- 1999/06/18 00:01 [medline]
PHST- 1999/06/18 00:00 [entrez]
AID - 10.1111/j.1749-6632.1999.tb08477.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 1999 Apr 30;872:328-34; discussion 334-5. doi: 
      10.1111/j.1749-6632.1999.tb08477.x.