PMID- 10372543
OWN - NLM
STAT- MEDLINE
DCOM- 19990812
LR  - 20190826
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 53
IP  - 5
DP  - 1999 May
TI  - Novel HLA-A and HLA-B alleles in South American Indians.
PG  - 476-85
AB  - The human leukocyte antigen (HLA) complex includes the most polymorphic genes in 
      humans. More than 600 allelic variants have been described in different 
      populations. The HLA-B locus has contributed the largest number of alleles. 
      Although Native American populations display a restricted number of HLA-alleles, 
      many novel HLA class I alleles have been identified in indigenous communities of 
      Central and South America. We have studied 248 unrelated individuals from three 
      tribes of North-East Argentina and one from South-West Brazil, as well as 80 
      related individuals from the Brazilian tribe. In the course of this work, we 
      found 8 new B-locus alleles and 2 novel A-locus alleles in these populations. 
      Here we report the nucleotide sequences of A*0219, A*0222, B*3519, B*3520, 
      B*3521, B*3912, B*4009 and B*4803 and we show their relationship with similar 
      alleles. The new alleles B*35092 and B*3518 have been described by us in a 
      previous paper. The possible mechanisms that may have produced these alleles over 
      evolutionary time are discussed.
FAU - Marcos, C Y
AU  - Marcos CY
AD  - Department of Internal Medicine, University of Texas, Southwestern Medical 
      Center, Dallas 75235-8886, USA.
FAU - Fernandez-Vina, M A
AU  - Fernandez-Vina MA
FAU - Lazaro, A M
AU  - Lazaro AM
FAU - Moraes, M E
AU  - Moraes ME
FAU - Moraes, J R
AU  - Moraes JR
FAU - Stastny, P
AU  - Stastny P
LA  - eng
SI  - GENBANK/L76931
SI  - GENBANK/L76933
SI  - GENBANK/L76934
SI  - GENBANK/L76936
SI  - GENBANK/U76390
SI  - GENBANK/U76391
SI  - GENBANK/U76392
SI  - GENBANK/U76393
SI  - GENBANK/U76394
SI  - GENBANK/U76395
SI  - GENBANK/U76398
SI  - GENBANK/U76399
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A2 Antigen)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B35 Antigen)
RN  - 0 (HLA-B39 Antigen)
RN  - 0 (HLA-B40 Antigen)
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Base Sequence
MH  - HLA-A2 Antigen/classification/*genetics
MH  - HLA-B Antigens/classification/*genetics
MH  - HLA-B35 Antigen/classification/*genetics
MH  - HLA-B39 Antigen
MH  - HLA-B40 Antigen
MH  - Humans
MH  - Indians, South American/*genetics
MH  - Molecular Sequence Data
MH  - Sequence Homology, Nucleic Acid
EDAT- 1999/06/18 00:00
MHDA- 1999/06/18 00:01
CRDT- 1999/06/18 00:00
PHST- 1999/06/18 00:00 [pubmed]
PHST- 1999/06/18 00:01 [medline]
PHST- 1999/06/18 00:00 [entrez]
AID - 10.1034/j.1399-0039.1999.530504.x [doi]
PST - ppublish
SO  - Tissue Antigens. 1999 May;53(5):476-85. doi: 10.1034/j.1399-0039.1999.530504.x.