PMID- 10372721
OWN - NLM
STAT- MEDLINE
DCOM- 19990702
LR  - 20220317
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 84
IP  - 6
DP  - 1999 Jun
TI  - The differential effect of food intake and beta-adrenergic stimulation on 
      adipose-derived hormones and cytokines in man.
PG  - 2126-33
AB  - We determined whether the physiologic changes that accompany food intake or 
      sympathetic activation by beta-adrenergic stimulation result in alterations in 
      the secretion of leptin, tumor necrosis factor-alpha (TNF alpha), or 
      interleukin-6 (IL-6) by serially sampling sc abdominal adipose interstitial fluid 
      by open-flow microperfusion before and after a standardized meal and in response 
      to isoproterenol (1 micromol/L) delivered locally. Post cibum IL-6 rose up to 
      5-fold, whereas leptin and TNF alpha secretion did not change; TNF alpha, but not 
      IL-6, correlated positively with indices of lipolysis. Isoproterenol-induced 
      lipolysis was accompanied by a transient 40% reduction in leptin and a parallel 
      85% elevation of TNF alpha concentration, whereas IL-6 levels did not change; 
      again, TNF alpha correlated positively with lipolysis. These data show that 
      secretion of some, but not all, metabolically relevant polypeptides by adipose 
      tissue is modulated within a short time frame by food or stress stimuli, 
      suggesting a role of these peptides in local autocrine/paracrine or distant 
      endocrine effects on fat metabolism. TNF alpha's close correlation with lipolysis 
      suggests that this cytokine participates in a local positive autocrine feedback 
      loop, potentiating lipolysis and inhibiting insulin's antilipolytic actions. The 
      regulations of adipose leptin, TNF alpha, and IL-6 secretion seem distinct from 
      each other and different in the fed vs. fasting state.
FAU - Orban, Z
AU  - Orban Z
AD  - Developmental Endocrinology Branch, National Institute of Child Health and Human 
      Development, Bethesda, Maryland 20892-1862, USA. orbanz@cc1.nichd.nih.gov
FAU - Remaley, A T
AU  - Remaley AT
FAU - Sampson, M
AU  - Sampson M
FAU - Trajanoski, Z
AU  - Trajanoski Z
FAU - Chrousos, G P
AU  - Chrousos GP
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Adrenergic beta-Agonists)
RN  - 0 (Cytokines)
RN  - 0 (Hormones)
RN  - 0 (Interleukin-6)
RN  - 0 (Leptin)
RN  - 0 (Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - L628TT009W (Isoproterenol)
SB  - IM
MH  - Adipose Tissue/drug effects/*metabolism
MH  - Adrenergic beta-Agonists/*pharmacology
MH  - Adult
MH  - Cytokines/*metabolism
MH  - Eating/*physiology
MH  - Fasting
MH  - Female
MH  - Hormones/*metabolism
MH  - Humans
MH  - Interleukin-6/blood
MH  - Isoproterenol/pharmacology
MH  - Leptin
MH  - Lipolysis/drug effects
MH  - Male
MH  - Postprandial Period
MH  - Proteins/metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 1999/06/18 00:00
MHDA- 1999/06/18 00:01
CRDT- 1999/06/18 00:00
PHST- 1999/06/18 00:00 [pubmed]
PHST- 1999/06/18 00:01 [medline]
PHST- 1999/06/18 00:00 [entrez]
AID - 10.1210/jcem.84.6.5747 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1999 Jun;84(6):2126-33. doi: 10.1210/jcem.84.6.5747.