PMID- 10372819
OWN - NLM
STAT- MEDLINE
DCOM- 19990729
LR  - 20240322
IS  - 0007-1188 (Print)
IS  - 0007-1188 (Linking)
VI  - 126
IP  - 8
DP  - 1999 Apr
TI  - The bradykinin B1 receptor and the central regulation of blood pressure in 
      spontaneously hypertensive rats.
PG  - 1769-76
AB  - 1. We evaluated if the brain bradykinin (BK) B1 receptor is involved in the 
      regulation of blood pressure (BP) in conscious rats. 2. Basal mean BP and HR were 
      115 +/- 2 and 165 +/- 3 mmHg and 345 +/- 10 and 410 +/- 14 beats min in Wistar 
      Kyoto (WKY) and spontaneously hypertensive rats (SHR), respectively. 
      Intracerebroventricular (i.c.v.) injection of 1 nmol B1 receptor agonist 
      Lys-desArg9-BK significantly increased the BP of WKY and SHR by 7+/-1 and 19+/-2 
      mmHg, respectively. One nmol Sar[D-Phe8]-desArg9-BK, a kininase-resistant B1 
      agonist, increased the BP of WKY and SHR by 19+/-2 and 17+/-2 mmHg, respectively 
      and reduced HR in both strains. 3. I.c.v. injection of 0.01 nmol B1 antagonists, 
      LysLeu8-desArg9-BK or AcLys[D-betaNal7,Ile8]-desArg9-BK (R715), significantly 
      decreased mean BP in SHR (by 9+/-2 mmHg the former and 14+/-3 mmHg the latter 
      compound), but not in WKY. In SHR, the BP response to R715 was associated to 
      tachycardia. 4. I.c.v. Captopril, a kininase inhibitor, increased the BP of SHR, 
      this response being partially prevented by i.c.v. R715 and reversed into a 
      vasodepressor effect by R715 in combination with the B2 antagonist Icatibant. 5. 
      I.c.v. antisense oligodeoxynucleotides (ODNs) targeted to the B1 receptor mRNA 
      decreased BP in SHR, but not in WKY. HR was not altered in either strain. 
      Distribution of fluorescein-conjugated ODNs was detected in brain areas 
      surrounding cerebral ventricles. 6. Our results indicate that the brain B1 
      receptor participates in the regulation of BP. Activation of the B1 receptor by 
      kinin metabolites could participate in the pathogenesis of hypertension in SHR.
FAU - Emanueli, C
AU  - Emanueli C
AD  - Laboratorio di Patologia Vascolare, Istituto Dermopatico dell'Immacolata, Rome, 
      Italy.
FAU - Chao, J
AU  - Chao J
FAU - Regoli, D
AU  - Regoli D
FAU - Chao, L
AU  - Chao L
FAU - Ni, A
AU  - Ni A
FAU - Madeddu, P
AU  - Madeddu P
LA  - eng
GR  - HL52196/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Br J Pharmacol
JT  - British journal of pharmacology
JID - 7502536
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Bradykinin Receptor Antagonists)
RN  - 0 (Oligonucleotides, Antisense)
RN  - 0 (Receptor, Bradykinin B1)
RN  - 0 (Receptor, Bradykinin B2)
RN  - 0 (Receptors, Bradykinin)
RN  - 0 (Thionucleotides)
RN  - 7PG89G35Q7 (icatibant)
RN  - 9G64RSX1XD (Captopril)
RN  - S8TIM42R2W (Bradykinin)
SB  - IM
MH  - Adrenergic beta-Antagonists/pharmacology
MH  - Animals
MH  - Antihypertensive Agents/antagonists & inhibitors/pharmacology
MH  - Blood Pressure/drug effects/*physiology
MH  - Bradykinin/analogs & derivatives/pharmacology
MH  - Bradykinin Receptor Antagonists
MH  - Brain/physiology
MH  - Captopril/antagonists & inhibitors/pharmacology
MH  - Heart Rate/drug effects/physiology
MH  - Hypertension/chemically induced/*physiopathology
MH  - Injections, Intraventricular
MH  - Male
MH  - Oligonucleotides, Antisense/pharmacology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Receptor, Bradykinin B1
MH  - Receptor, Bradykinin B2
MH  - Receptors, Bradykinin/agonists/*physiology
MH  - Thionucleotides/pharmacology
PMC - PMC1565971
EDAT- 1999/06/18 00:00
MHDA- 1999/06/18 00:01
PMCR- 2000/04/01
CRDT- 1999/06/18 00:00
PHST- 1999/06/18 00:00 [pubmed]
PHST- 1999/06/18 00:01 [medline]
PHST- 1999/06/18 00:00 [entrez]
PHST- 2000/04/01 00:00 [pmc-release]
AID - 0702527 [pii]
AID - 10.1038/sj.bjp.0702527 [doi]
PST - ppublish
SO  - Br J Pharmacol. 1999 Apr;126(8):1769-76. doi: 10.1038/sj.bjp.0702527.