PMID- 10373115
OWN - NLM
STAT- MEDLINE
DCOM- 19990707
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 284
IP  - 5422
DP  - 1999 Jun 18
TI  - Gating of BDNF-induced synaptic potentiation by cAMP.
PG  - 1982-4
AB  - Neurotrophins have been implicated in activity-dependent synaptic plasticity, but 
      the underlying intracellular mechanisms remain largely unknown. Synaptic 
      potentiation induced by brain-derived neurotrophic factor (BDNF), but not 
      neurotrophin 3, was prevented by blockers of adenosine 3',5'-monophosphate (cAMP) 
      signaling. Activators of cAMP signaling alone were ineffective in modifying 
      synaptic efficacy but greatly enhanced the potentiation effect of BDNF. Blocking 
      cAMP signaling abolished the facilitation of BDNF-induced potentiation by 
      presynaptic activity. Thus synaptic actions of BDNF are gated by cAMP. Activity 
      and other coincident signals that modulate cAMP concentrations may specify the 
      action of secreted neurotrophins on developing nerve terminals.
FAU - Boulanger, L
AU  - Boulanger L
AD  - Department of Biology, University of California at San Diego, La Jolla, CA 
      92093-0357, USA.
FAU - Poo, M M
AU  - Poo MM
LA  - eng
GR  - NS 37831/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carbazoles)
RN  - 0 (Indoles)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - 0 (Pyrroles)
RN  - 0 (Thionucleotides)
RN  - 0TQU7668EI (Cycloleucine)
RN  - 111900-32-4 (1-amino-1,3-dicarboxycyclopentane)
RN  - 1W21G5Q4N2 (Okadaic Acid)
RN  - 23645-17-2 (adenosine-3',5'-cyclic phosphorothioate)
RN  - 58HV29I28S (KT 5720)
RN  - E0399OZS9N (Cyclic AMP)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - *Carbazoles
MH  - Cells, Cultured
MH  - Cyclic AMP/analogs & derivatives/pharmacology/*physiology
MH  - Cycloleucine/analogs & derivatives/pharmacology
MH  - *Excitatory Postsynaptic Potentials/drug effects
MH  - Indoles/pharmacology
MH  - Nerve Growth Factors/pharmacology
MH  - Neuronal Plasticity
MH  - Neurons/cytology/physiology
MH  - Neurotrophin 3
MH  - Okadaic Acid/pharmacology
MH  - Patch-Clamp Techniques
MH  - Pyrroles/pharmacology
MH  - Signal Transduction
MH  - Synapses/drug effects/*physiology
MH  - *Synaptic Transmission/drug effects
MH  - Thionucleotides/pharmacology
MH  - Xenopus
EDAT- 1999/06/18 00:00
MHDA- 1999/06/18 00:01
CRDT- 1999/06/18 00:00
PHST- 1999/06/18 00:00 [pubmed]
PHST- 1999/06/18 00:01 [medline]
PHST- 1999/06/18 00:00 [entrez]
AID - 7589 [pii]
AID - 10.1126/science.284.5422.1982 [doi]
PST - ppublish
SO  - Science. 1999 Jun 18;284(5422):1982-4. doi: 10.1126/science.284.5422.1982.