PMID- 10374380
OWN - NLM
STAT- MEDLINE
DCOM- 19990727
LR  - 20220317
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 111
IP  - 2
DP  - 1998 Feb
TI  - HLA-DQA1, -DQB1 polymorphism distribution in Chinese women with pregnancy induced 
      hypertension in Shanghai area.
PG  - 163-5
AB  - OBJECTIVE: To explore the association of human leukocyte antigen (HLA) with 
      pregnancy induced hypertension (PIH). METHODS: We oligotyped HLA-DQA1, -DQB1 
      locus of 30 Chinese PIH families and 14 control families in Shanghai area by 
      polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) 
      hybridization method (probes labeled by nonradioactive technique). RESULTS: 
      Compared with the control group, the allelic frequency of HLA-DQB1 * 0502 was 
      significantly higher in PIH couples, and the sharing of HLA-DQA1 increased in PIH 
      couples as well. No difference was found in HLA-DQA1 allelic frequencies or 
      HLA-DQB1 sharing between the two groups. Analysis of neither HLA-DQA1 nor 
      HLA-DQB1 allelic frequencies in PIH patients and PIH mother-and-fetuses showed 
      positive result. CONCLUSION: HLA-DQB1 * 0502 may be a marker of susceptibility to 
      PIH. DQB1 * 0502 itself or some gene(s) located in HLA class II region and in 
      linkage disequilibrium with 0502 affect maternal T cell immunity during 
      pregnancy. The increase of compatibility in HLA-D region causes the production of 
      blocking antibody to decrease.
FAU - Mao, Y
AU  - Mao Y
AD  - Obstetrics and Gynecology Hospital of Shanghai Medical University, Shanghai, 
      China.
FAU - Zhang, Z
AU  - Zhang Z
FAU - Fan, L
AU  - Fan L
FAU - Wu, Q
AU  - Wu Q
FAU - Jiang, L
AU  - Jiang L
FAU - Yang, J
AU  - Yang J
FAU - Yao, F
AU  - Yao F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Pre-Eclampsia/*immunology
MH  - Pregnancy
EDAT- 1999/06/22 00:00
MHDA- 1999/06/22 00:01
CRDT- 1999/06/22 00:00
PHST- 1999/06/22 00:00 [pubmed]
PHST- 1999/06/22 00:01 [medline]
PHST- 1999/06/22 00:00 [entrez]
PST - ppublish
SO  - Chin Med J (Engl). 1998 Feb;111(2):163-5.