PMID- 10374869
OWN - NLM
STAT- MEDLINE
DCOM- 19990629
LR  - 20190915
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 13
IP  - 5
DP  - 1999 May
TI  - Centric and pericentric chromosome rearrangements in hematopoietic malignancies.
PG  - 671-8
AB  - Cytogenetic and fluorescence in situ hybridization (FISH) analysis of 10 patients 
      with various hematopoietic malignancies revealed the presence of dicentric 
      chromosomes or pericentric chromosome rearrangements. Dicentrics were only 
      ascertained by FISH studies in six patients. Two types of pericentric chromosome 
      rearrangements have been observed: 'classical' dicentrics with two clearly 
      separated centromeric regions, and more unusual rearrangements with a breakpoint 
      within the centromeric or heterochromatic area, but outside the alphoid domain. 
      FISH analysis of partial chromosome 1 q duplications present in three Burkitt 
      lymphoma cell lines confirmed the partial involvement of the non-alphoid 
      centromeric domain in the duplicated chromosome segment. The incidence of 
      centromeric and pericentromeric rearrangements in hematopoietic malignancies may 
      be higher than hitherto admitted. The chromosomal localization of these 
      rearrangements suggests several mechanisms possibly involved in the malignant 
      process and deserves more systematic study.
FAU - Berger, R
AU  - Berger R
AD  - INSERM U434 and CNRS SD 401 No. 434, Institut de Genetique Moleculaire, Paris, 
      France.
FAU - Busson-Le Coniat, M
AU  - Busson-Le Coniat M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - *Chromosome Aberrations
MH  - Female
MH  - Hematologic Neoplasms/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Tumor Cells, Cultured
RF  - 84
EDAT- 1999/06/22 00:00
MHDA- 1999/06/22 00:01
CRDT- 1999/06/22 00:00
PHST- 1999/06/22 00:00 [pubmed]
PHST- 1999/06/22 00:01 [medline]
PHST- 1999/06/22 00:00 [entrez]
AID - 10.1038/sj.leu.2401365 [doi]
PST - ppublish
SO  - Leukemia. 1999 May;13(5):671-8. doi: 10.1038/sj.leu.2401365.