PMID- 10374885
OWN - NLM
STAT- MEDLINE
DCOM- 19990629
LR  - 20190915
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 13
IP  - 5
DP  - 1999 May
TI  - Frequent chromosome arm 13q deletion in aggressive non-Hodgkin's lymphoma.
PG  - 792-8
AB  - To clarify the role of allelic loss on chromosome arm 13q in lymphomagenesis, we 
      performed fluorescence in situ hybridization (FISH) analysis of a total of 43 
      primary lymphomas, including both indolent and aggressive non-Hodgkin's lymphoma 
      (NHL) and Hodgkin's disease (HD), using the specific probes at RB1 and D13S319 
      loci on the centromeric portion of chromosome arm 13q. Monosomy at either or both 
      RB1 and D13S319 loci was detected in 15 of 43 (35%) lymphomas (14 of 43 cases at 
      RB1 locus and seven of 43 cases at D13S319 locus); the 13q deletion was 
      frequently detected in the aggressive NHLs (40%; 12 of 30 cases) compared with 
      that in indolent NHL (17%; one of six cases) and a subset of HD (29%; two of 
      seven cases). There are only six cases of 43 which have total monosomy 13q14, all 
      aggressive NHL, 14% of total or 20% of this subgroup. In addition, we analyzed 
      the loss of heterozygosity in 15 of the 43 primary lymphoma samples for several 
      polymorphic microsatellite loci (D13S168, RB1 and D13S272) on the chromosome arm 
      13q, and confirmed the 13q deletion in four of five cases that were positive on 
      FISH analysis. The subchromosomal region frequently altered in lymphoma on 13q14 
      is the region around RB1 locus and centromeric to D13S319 locus, which is an 
      overlapped region frequently deleted in chronic lymphocytic leukemia. Together, 
      our data indicate that the 13q alterations are present in a variety of types of 
      lymphoma and occur in a significant proportion of aggressive NHLs, suggesting the 
      possible presence of common candidate gene(s) on the 13q14 region, whose 
      alteration may play an important role in the formation or development of a wide 
      variety of mature lymphoid malignancies.
FAU - Wada, M
AU  - Wada M
AD  - Department of Hematology, Tokyo Women's Medical University, Japan.
FAU - Okamura, T
AU  - Okamura T
FAU - Okada, M
AU  - Okada M
FAU - Teramura, M
AU  - Teramura M
FAU - Masuda, M
AU  - Masuda M
FAU - Motoji, T
AU  - Motoji T
FAU - Mizoguchi, H
AU  - Mizoguchi H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Chromosome Deletion
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 13
MH  - Female
MH  - Genes, Retinoblastoma
MH  - Genes, Tumor Suppressor
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Loss of Heterozygosity
MH  - Lymphoma, Non-Hodgkin/*genetics
MH  - Male
MH  - Middle Aged
EDAT- 1999/06/22 00:00
MHDA- 1999/06/22 00:01
CRDT- 1999/06/22 00:00
PHST- 1999/06/22 00:00 [pubmed]
PHST- 1999/06/22 00:01 [medline]
PHST- 1999/06/22 00:00 [entrez]
AID - 10.1038/sj.leu.2401395 [doi]
PST - ppublish
SO  - Leukemia. 1999 May;13(5):792-8. doi: 10.1038/sj.leu.2401395.