PMID- 10375592
OWN - NLM
STAT- MEDLINE
DCOM- 19990805
LR  - 20190516
IS  - 1019-6439 (Print)
IS  - 1019-6439 (Linking)
VI  - 15
IP  - 1
DP  - 1999 Jul
TI  - Cytogenetic and CGH studies of four neuroendocrine tumors and tumor-derived cell 
      lines of a patient with multiple endocrine neoplasia type 1.
PG  - 41-51
AB  - A malignant insulinoma (LOHG-I), a carcinoid of the lung (LOHG-L), a parathyroid 
      adenoma (LOHG-NSA), and a fibroma (LOHG-F) were obtained from a patient with 
      multiple endocrine neoplasia type 1 (MEN1). Long-term cultures were established. 
      Essential neurobiological properties of the cell lines were proven 
      immunocytochemically and by electron microscopy. Molecular analysis of the 
      germline DNA showed a 4 bp deletion in exon 3 of the MEN1 gene. Cytogenetic and 
      CGH analyses of the tumors/tumor cell lines revealed diploidy and balanced and 
      unbalanced structural aberrations different for each tumor. Chromosomes 6q21, 11q 
      and 17q were most frequently involved in clonal structural aberrations.
FAU - Sigl, E
AU  - Sigl E
AD  - Department of General and Experimental Pathology, University of Graz, Graz, 
      Austria.
FAU - Behmel, A
AU  - Behmel A
FAU - Henn, T
AU  - Henn T
FAU - Wirnsberger, G
AU  - Wirnsberger G
FAU - Weinhausl, A
AU  - Weinhausl A
FAU - Kaserer, K
AU  - Kaserer K
FAU - Niederle, B
AU  - Niederle B
FAU - Pfragner, R
AU  - Pfragner R
LA  - eng
PT  - Case Reports
PT  - Comparative Study
PT  - Journal Article
PL  - Greece
TA  - Int J Oncol
JT  - International journal of oncology
JID - 9306042
RN  - 0 (DNA, Neoplasm)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Adenoma/*genetics/pathology
MH  - Adrenal Gland Neoplasms/pathology
MH  - Adult
MH  - Aneuploidy
MH  - Carcinoid Tumor/*genetics/pathology
MH  - Chromosome Aberrations
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - DNA Mutational Analysis
MH  - *DNA, Neoplasm/genetics
MH  - Esophageal Neoplasms/pathology
MH  - Fibroma/*genetics/pathology
MH  - *Genes, Tumor Suppressor
MH  - Humans
MH  - Insulinoma/*genetics/pathology
MH  - Leiomyoma/pathology
MH  - Lung Neoplasms/*genetics/pathology
MH  - Male
MH  - Multiple Endocrine Neoplasia Type 1/*genetics/pathology
MH  - Neoplasm Proteins/*deficiency/genetics/physiology
MH  - Nucleic Acid Hybridization
MH  - Pancreatic Neoplasms/*genetics/pathology
MH  - Parathyroid Neoplasms/*genetics/pathology
MH  - Pheochromocytoma/pathology
MH  - *Proto-Oncogene Proteins
MH  - Sequence Deletion
MH  - Skin Neoplasms/*genetics/pathology
MH  - Tumor Cells, Cultured
EDAT- 1999/06/22 00:00
MHDA- 1999/06/22 00:01
CRDT- 1999/06/22 00:00
PHST- 1999/06/22 00:00 [pubmed]
PHST- 1999/06/22 00:01 [medline]
PHST- 1999/06/22 00:00 [entrez]
AID - 10.3892/ijo.15.1.41 [doi]
PST - ppublish
SO  - Int J Oncol. 1999 Jul;15(1):41-51. doi: 10.3892/ijo.15.1.41.