PMID- 10375691
OWN - NLM
STAT- MEDLINE
DCOM- 19990813
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 833
IP  - 2
DP  - 1999 Jul 3
TI  - Regional changes in the expression of neurotrophic factors and their receptors 
      following acute traumatic brain injury in the adult rat brain.
PG  - 161-72
AB  - We have analyzed the effect of severe traumatic brain injury (TBI) on the levels 
      of mRNA expression of neurotrophic factors (NTFs): brain-derived neurotrophic 
      factor (BDNF), nerve growth factor (NGF), ciliary neurotrophic factor (CNTF) and 
      their respective receptors: trkB, trkA and CNTFRalpha. The expression was 
      examined in the region of the lesion as well as a region remote from the lesion 
      at 12, 24, and 36 h following the injury. Our data suggest that after the brain 
      injury, the expression of NGF and BDNF mRNAs were early, transiently and 
      significantly upregulated while that of CNTF was a slow and less amplified 
      response in both areas of the brain. We also found that trkA mRNA expression was 
      only upregulated significantly in the remote area; trkB mRNA showed no 
      significant change in either area except an upregulation at 12 h in the remote 
      area. CNTFRalpha was downregulated significantly by 24-36 h in the lesion area 
      and by 24 h in the remote area. These changes suggest that TBI regulates the 
      expression of NTFs and their receptors. These alterations in expression may be 
      involved in modulating the neuronal response after brain injury.
CI  - Copyright 1999 Elsevier Science B.V.
FAU - Oyesiku, N M
AU  - Oyesiku NM
AD  - Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA 
      30322, USA. noyesik@emory.edu
FAU - Evans, C O
AU  - Evans CO
FAU - Houston, S
AU  - Houston S
FAU - Darrell, R S
AU  - Darrell RS
FAU - Smith, J S
AU  - Smith JS
FAU - Fulop, Z L
AU  - Fulop ZL
FAU - Dixon, C E
AU  - Dixon CE
FAU - Stein, D G
AU  - Stein DG
LA  - eng
GR  - CCR49/CCR412307/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Ciliary Neurotrophic Factor)
RN  - 0 (DNA Primers)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptor, Ciliary Neurotrophic Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, trkA)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Blotting, Northern
MH  - Brain Chemistry/genetics
MH  - Brain Injuries/*physiopathology
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Ciliary Neurotrophic Factor
MH  - DNA Primers
MH  - Gene Expression/physiology
MH  - Male
MH  - Nerve Growth Factors/*genetics
MH  - Nerve Tissue Proteins/genetics
MH  - Neuronal Plasticity/physiology
MH  - Proto-Oncogene Proteins/genetics
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor Protein-Tyrosine Kinases/*genetics
MH  - Receptor, Ciliary Neurotrophic Factor
MH  - Receptor, trkA
MH  - Receptors, Nerve Growth Factor/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 1999/06/22 00:00
MHDA- 1999/06/22 00:01
CRDT- 1999/06/22 00:00
PHST- 1999/06/22 00:00 [pubmed]
PHST- 1999/06/22 00:01 [medline]
PHST- 1999/06/22 00:00 [entrez]
AID - S0006-8993(99)01501-2 [pii]
AID - 10.1016/s0006-8993(99)01501-2 [doi]
PST - ppublish
SO  - Brain Res. 1999 Jul 3;833(2):161-72. doi: 10.1016/s0006-8993(99)01501-2.