PMID- 10378384
OWN - NLM
STAT- MEDLINE
DCOM- 20000114
LR  - 20190812
IS  - 0001-6322 (Print)
IS  - 0001-6322 (Linking)
VI  - 97
IP  - 6
DP  - 1999 Jun
TI  - Local expression of monocyte chemoattractant protein-1 (MCP-1) in idiopathic 
      inflammatory myopathies.
PG  - 642-8
AB  - The idiopathic inflammatory myopathies (IIM), including dermatomyositis (DM), 
      polymyositis (PM), and inclusion body myositis (IBM), are a group of autoimmune 
      diseases characterized by the recruitment of lymphocytes and monocytes to the 
      site of affection. The mechanism for recruitment of these cells likely involves 
      chemokines. The monocyte chemoattractant protein-1 (MCP-1), a chemoattractant to 
      T lymphocytes and monocytes, may play an important role in the pathogenesis of 
      IIM. Frozen muscular tissues were obtained from eight cases of DM, five PM, and 
      four IBM. We investigated the MCP-1 expression by the reverse transcription-PCR 
      technique, immunohistochemistry and in situ hybridization. MCP-1 mRNA was 
      markedly expressed in all the IIM cases. Greater amounts of MCP-1 mRNA were 
      observed in DM, and in situ hybridization showed MCP-1 mRNA accumulation in 
      perivascular mononuclear cells. Immunohistochemistry showed MCP-1 expression in 
      vessels (endothelial cells and walls of veins and arteries) in all IIM cases. 
      Very few mononuclear cells in DM perivascular infiltrates expressed MCP-1, 
      whereas in PM and IBM, it was strongly expressed by mononuclear cells partially 
      invading non-necrotic muscle fibers. These findings suggest that MCP-1 can 
      contribute to the inflammatory response by attracting monocytes and T lymphocytes 
      to sites of cell-mediated immune injury. The morphological characteristics and 
      distribution of positive cells indicate that macrophages, lymphocytes, and 
      endothelial cells previously reported to produce MCP-1, contribute to its 
      production in IIM lesions.
FAU - Liprandi, A
AU  - Liprandi A
AD  - Laboratoire de Biopathologie Nerveuse et Musculaire, Faculte de Medecine, JE 
      2053, IBDM Marseille, France.
FAU - Bartoli, C
AU  - Bartoli C
FAU - Figarella-Branger, D
AU  - Figarella-Branger D
FAU - Pellissier, J F
AU  - Pellissier JF
FAU - Lepidi, H
AU  - Lepidi H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Acta Neuropathol
JT  - Acta neuropathologica
JID - 0412041
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chemokine CCL2/*analysis
MH  - Female
MH  - Gene Expression
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Inflammation/pathology
MH  - Male
MH  - Middle Aged
MH  - Muscles/pathology
MH  - Myositis/*pathology
MH  - Polymerase Chain Reaction
EDAT- 1999/06/23 00:00
MHDA- 1999/06/23 00:01
CRDT- 1999/06/23 00:00
PHST- 1999/06/23 00:00 [pubmed]
PHST- 1999/06/23 00:01 [medline]
PHST- 1999/06/23 00:00 [entrez]
AID - 10.1007/s004010051041 [doi]
PST - ppublish
SO  - Acta Neuropathol. 1999 Jun;97(6):642-8. doi: 10.1007/s004010051041.