PMID- 10378743
OWN - NLM
STAT- MEDLINE
DCOM- 19990720
LR  - 20190921
IS  - 1388-2457 (Print)
IS  - 1388-2457 (Linking)
VI  - 110
IP  - 4
DP  - 1999 Apr
TI  - Changes in motor evoked potentials to short-interval paired transcranial magnetic 
      stimuli in multiple sclerosis.
PG  - 712-9
AB  - OBJECTIVE: Paired transcranial magnetic stimuli (TMS) were applied in 8 multiple 
      sclerosis (MS) patients with asymmetrical clinical signs and in 8 healthy 
      controls to test the hypothesis that the circuits responsible for the generation 
      and transmission of I-waves are abnormal in the former group METHODS: A 
      figure-of-8 coil discharging through a Magstim 200/Bistim configuration delivered 
      identical stimuli at an intensity 10% above the motor threshold of the relaxed 
      first dorsal interosseous muscle. The interstimulus intervals (ISIs) used were 
      varied in a pseudo-randomized fashion in steps of 0.2 ms between 1.0 and 5 ms. 
      RESULTS: In 9 of 12 unilateral studies in the control group, a pattern of 3 peaks 
      of increased motor evoked potential size was found at ISIs of 1.2-1.6 ms, 2.4-3.2 
      ms and 4.4-5.0 ms. A similar pattern was present in only 5 of 12 studies in the 
      patients (Fisher's exact test, P = 0.1), while it was absent in all the 4 studies 
      of the side with greater clinical involvement in patients (P = 0.01) CONCLUSION: 
      Our results suggest that I-wave generation is more likely to be defective in MS 
      than in normal subjects, that this defect resides in the cortex, and that it 
      correlates with severity of physical signs.
FAU - Ho, K H
AU  - Ho KH
AD  - University Department of Clinical Neurology, The Radcliffe Infirmary, Oxford, UK.
FAU - Lee, M
AU  - Lee M
FAU - Nithi, K
AU  - Nithi K
FAU - Palace, J
AU  - Palace J
FAU - Mills, K
AU  - Mills K
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Adult
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Humans
MH  - *Magnetics
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*physiopathology
MH  - Time Factors
EDAT- 1999/06/23 00:00
MHDA- 1999/06/23 00:01
CRDT- 1999/06/23 00:00
PHST- 1999/06/23 00:00 [pubmed]
PHST- 1999/06/23 00:01 [medline]
PHST- 1999/06/23 00:00 [entrez]
AID - S1388245798000480 [pii]
AID - 10.1016/s1388-2457(98)00048-0 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 1999 Apr;110(4):712-9. doi: 10.1016/s1388-2457(98)00048-0.