PMID- 10378845
OWN - NLM
STAT- MEDLINE
DCOM- 19990624
LR  - 20190727
IS  - 0041-1132 (Print)
IS  - 0041-1132 (Linking)
VI  - 39
IP  - 6
DP  - 1999 Jun
TI  - Human T-lymphotropic virus type I among blood donors from Guadeloupe: donation, 
      demographic, and biologic characteristics.
PG  - 639-44
AB  - BACKGROUND: Epidemiologic data on human T-lymphotropic virus type I (HTLV-I) in 
      Guadeloupe (French West Indies) are scant. STUDY DESIGN AND METHODS: From January 
      1989 to December 1996, 59,426 blood donors were screened by enzyme immunoassay 
      for antibodies to HTLV-I. All repeatedly reactive samples were confirmed by 
      Western blot. Temporal trends in HTLV-I seropositivity rates were examined during 
      the study period. A multivariate analysis of donation, demographic, and biologic 
      characteristics was performed. RESULTS: Of the screened blood donors, 195 were 
      confirmed as seropositive, for an overall prevalence of 0.33 percent (95% CI 
      0.28-0.38). A marked decrease in overall HTLV-I prevalence with time (from 0.47% 
      in 1989 to 0.13% in 1996) was observed, which can be explained mainly by the 
      decreasing percentage of recruited new donors during the study period. Four 
      independent risk factors for HTLV-I were identified: new donor status (odds ratio 
      [OR] 12.5), female sex (OR 1.7), increasing age (30-39 years: OR, 2.4; 40-49 
      years: OR, 3.7; >50 years: OR 6.6), and positive antibodies to hepatitis B virus 
      core antigen (OR, 1.7). Selection of specific locations for blood collection was 
      inversely associated with HTLV-I (OR 0.5). CONCLUSION: New donor status, 
      advancing age, female sex, and positivity for hepatitis B virus core antibodies 
      were the major factors associated with HTLV-I infection in Guadeloupe.
FAU - Rouet, F
AU  - Rouet F
AD  - Etablissement de Transfusion Sanguine, Pointe-a-Pitre, Guadeloupe, France. 
      rouet.francois@wanadoo.fr
FAU - Foucher, C
AU  - Foucher C
FAU - Rabier, M
AU  - Rabier M
FAU - Gawronski, I
AU  - Gawronski I
FAU - Taverne, D
AU  - Taverne D
FAU - Chancerel, B
AU  - Chancerel B
FAU - Casman, O
AU  - Casman O
FAU - Strobel, M
AU  - Strobel M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
SB  - IM
MH  - *Blood Donors
MH  - HTLV-I Infections/blood/*transmission
MH  - *Human T-lymphotropic virus 1
MH  - Humans
MH  - Multivariate Analysis
MH  - Seroepidemiologic Studies
MH  - West Indies
EDAT- 1999/06/23 00:00
MHDA- 1999/06/23 00:01
CRDT- 1999/06/23 00:00
PHST- 1999/06/23 00:00 [pubmed]
PHST- 1999/06/23 00:01 [medline]
PHST- 1999/06/23 00:00 [entrez]
AID - 10.1046/j.1537-2995.1999.39060639.x [doi]
PST - ppublish
SO  - Transfusion. 1999 Jun;39(6):639-44. doi: 10.1046/j.1537-2995.1999.39060639.x.