PMID- 10378987
OWN - NLM
STAT- MEDLINE
DCOM- 19990908
LR  - 20151119
IS  - 1043-6618 (Print)
IS  - 1043-6618 (Linking)
VI  - 40
IP  - 1
DP  - 1999 Jul
TI  - The evaluation of the antianaphylactic effect of Oryza sativa L. subsp. hsien 
      Ting in rats.
PG  - 31-6
AB  - We studied the effect of the methanol extract of Oryza sativa L. subsp. hsien 
      Ting (OSHT) on anaphylaxis. OSHT (0.001-1.0 mg g-1body weight (BW)) 
      dose-dependently inhibited systemic anaphylaxis induced by compound 48/80 in 
      rats. When OSHT was pretreated at concentrations ranging from 0.001 to 1.0 mg 
      g-1BW, the serum histamine levels were reduced in a dose-dependent manner. OSHT 
      (0. 001-1.0 mg g-1BW) also inhibited local anaphylaxis activated by 
      anti-dinitrophenyl (DNP) IgE. Moreover, OSHT dose-dependently inhibited the 
      histamine release from rat peritoneal mast cells (RPMC) activated by compound 
      48/80 or anti-DNP IgE. The level of cAMP in RPMC, when OSHT was added, 
      significantly increased approx. 20-fold compared with that of basal cells. These 
      results indicate that OSHT possesses strong antianaphylactic activity by 
      inhibition of histamine release from mast cells in vivo and in vitro.
CI  - Copyright 1999 Academic Press.
FAU - Kim, H M
AU  - Kim HM
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, 
      Chonbuk, 570-749, South Korea.
FAU - Kang, C S
AU  - Kang CS
FAU - Lee, E H
AU  - Lee EH
FAU - Shin, T Y
AU  - Shin TY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
RN  - 0 (Plant Extracts)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - E0399OZS9N (Cyclic AMP)
SB  - IM
MH  - Anaphylaxis/chemically induced/*prevention & control
MH  - Animals
MH  - Cyclic AMP/metabolism
MH  - Disease Models, Animal
MH  - Evaluation Studies as Topic
MH  - Histamine Release/drug effects
MH  - Mast Cells/drug effects/metabolism
MH  - Oryza/*chemistry
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - Plant Extracts/pharmacology/therapeutic use
MH  - Plants, Medicinal/*chemistry
MH  - Rats
MH  - Rats, Wistar
MH  - p-Methoxy-N-methylphenethylamine
EDAT- 1999/06/24 00:00
MHDA- 1999/06/24 00:01
CRDT- 1999/06/24 00:00
PHST- 1999/06/24 00:00 [pubmed]
PHST- 1999/06/24 00:01 [medline]
PHST- 1999/06/24 00:00 [entrez]
AID - S1043-6618(98)90386-3 [pii]
AID - 10.1006/phrs.1998.0386 [doi]
PST - ppublish
SO  - Pharmacol Res. 1999 Jul;40(1):31-6. doi: 10.1006/phrs.1998.0386.