PMID- 10378992
OWN - NLM
STAT- MEDLINE
DCOM- 19990908
LR  - 20240109
IS  - 1043-6618 (Print)
IS  - 1043-6618 (Linking)
VI  - 40
IP  - 1
DP  - 1999 Jul
TI  - Inhibitory effect of mast cell-mediated immediate-type allergic reactions by 
      Cichorium intybus.
PG  - 61-5
AB  - We investigated the effect of an aqueous extract of Cichorium intybus (CIAE) on 
      mast cell-mediated immediate type allergic reactions. CIAE (0.1-1000 mg kg-1) 
      dose-dependently inhibited systemic anaphylactic reaction induced by compound 
      48/80 in mice. Especially, CIAE inhibited compound 48/80-induced anaphylactic 
      reaction 100% with the dose of 1000 mg kg-1. CIAE 1000 mg kg-1also significantly 
      inhibited local anaphylactic reaction activated by anti-dinitrophenyl (DNP) IgE. 
      When mice were pretreated with CIAE at a concentration ranging from 0.1 to 1000 
      mg kg-1, the plasma histamine levels were reduced in a dose-dependent manner. 
      CIAE (1-1000 microg ml-1) dose-dependently inhibited histamine release from the 
      rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. The 
      level of cAMP in RPMC, when CIAE (1000 microg ml-1) was added, increased 
      significantly compared with that of control cells. These results indicate that 
      CIAE inhibits mast cell-mediated immediate-type allergic reactions in vivo and in 
      vitro.
CI  - Copyright 1999 Academic Press.
FAU - Kim, H M
AU  - Kim HM
AD  - College of Pharmacy, Wonkwang University, Iksan, Chonbuk, 570-749, South Korea.
FAU - Kim, H W
AU  - Kim HW
FAU - Lyu, Y S
AU  - Lyu YS
FAU - Won, J H
AU  - Won JH
FAU - Kim, D K
AU  - Kim DK
FAU - Lee, Y M
AU  - Lee YM
FAU - Morii, E
AU  - Morii E
FAU - Jippo, T
AU  - Jippo T
FAU - Kitamura, Y
AU  - Kitamura Y
FAU - An, N H
AU  - An NH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Plant Extracts)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - E0399OZS9N (Cyclic AMP)
SB  - IM
MH  - Anaphylaxis/chemically induced/prevention & control
MH  - Animals
MH  - Anti-Allergic Agents/*therapeutic use
MH  - Cichorium intybus/chemistry/*therapeutic use
MH  - Cyclic AMP/metabolism
MH  - Histamine Release/drug effects
MH  - Hypersensitivity, Immediate/*drug therapy
MH  - Mast Cells/*drug effects/physiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Passive Cutaneous Anaphylaxis/*drug effects
MH  - *Phytotherapy
MH  - Plant Extracts/pharmacology/therapeutic use
MH  - Rats
MH  - Rats, Wistar
MH  - p-Methoxy-N-methylphenethylamine
EDAT- 1999/06/24 00:00
MHDA- 1999/06/24 00:01
CRDT- 1999/06/24 00:00
PHST- 1999/06/24 00:00 [pubmed]
PHST- 1999/06/24 00:01 [medline]
PHST- 1999/06/24 00:00 [entrez]
AID - S1043-6618(99)90474-7 [pii]
AID - 10.1006/phrs.1999.0474 [doi]
PST - ppublish
SO  - Pharmacol Res. 1999 Jul;40(1):61-5. doi: 10.1006/phrs.1999.0474.