PMID- 10378995
OWN - NLM
STAT- MEDLINE
DCOM- 19990908
LR  - 20150831
IS  - 1043-6618 (Print)
IS  - 1043-6618 (Linking)
VI  - 40
IP  - 1
DP  - 1999 Jul
TI  - The cost-effectiveness of low-molecular-weight heparin vs unfractionated heparin 
      in general and orthopaedic surgery: an analysis for the German healthcare system.
PG  - 83-9
AB  - BACKGROUND: Studies over the last years provided empirical evidence that 
      low-molecular weight heparins (LMWH) have advantages over unfractionated heparin 
      (UFH) as post-operative thromboprophylactic agents. A detailed perspective 
      economic evaluation for Germany is not available. METHODS: A deterministic 
      decision-tree analysis was developed to estimate the main cost-relevant 
      pathophysiological events: deep vein thrombosis (DTV), pulmonary embolism (PE) 
      and major bleeding complications (BC) in general and orthopaedic surgery. The 
      specific costs were analysed, summed up and put into relation with saved 
      lifeyears from the perspective of society, third party payer and hospital 
      management. The robustness of these results were substantiated by a detailed 
      sensitivity analysis. RESULT: LMWH avoids pathophysiological events, saves costs 
      and lifeyears in general and orthopaedic surgery from all perspectives. 
      CONCLUSION: The use of LMWH as post-operative thromboprophylactic agents is more 
      cost-effective than UFH in Germany.
CI  - Copyright 1999 Academic Press.
FAU - Szucs, T D
AU  - Szucs TD
AD  - Centre of Pharmacoeconomics, Institute of Pharmacological Sciences, University of 
      Milan, via Balzaretti, 9, Milan, 20133, Italy.
FAU - Schramm, W
AU  - Schramm W
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
RN  - 0 (Fibrinolytic Agents)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Cohort Studies
MH  - Cost-Benefit Analysis
MH  - Delivery of Health Care/*economics
MH  - Fibrinolytic Agents/chemistry/*economics
MH  - General Surgery/*economics
MH  - Germany
MH  - Heparin/chemistry/*economics
MH  - Humans
MH  - Molecular Weight
MH  - Orthopedics/*economics
MH  - Postoperative Care/economics
MH  - Retrospective Studies
EDAT- 1999/06/24 00:00
MHDA- 1999/06/24 00:01
CRDT- 1999/06/24 00:00
PHST- 1999/06/24 00:00 [pubmed]
PHST- 1999/06/24 00:01 [medline]
PHST- 1999/06/24 00:00 [entrez]
AID - S1043-6618(99)90479-6 [pii]
AID - 10.1006/phrs.1999.0479 [doi]
PST - ppublish
SO  - Pharmacol Res. 1999 Jul;40(1):83-9. doi: 10.1006/phrs.1999.0479.