PMID- 10380002
OWN - NLM
STAT- MEDLINE
DCOM- 19990910
LR  - 20190910
IS  - 0021-9304 (Print)
IS  - 0021-9304 (Linking)
VI  - 46
IP  - 2
DP  - 1999 Aug
TI  - In vitro degradation of thin poly(DL-lactic-co-glycolic acid) films.
PG  - 236-44
AB  - This study was designed to investigate the in vitro degradation of thin 
      poly(DL-lactic-co-glycolic acid) (PLGA) films for applications in retinal pigment 
      epithelium transplantation and guided tissue regeneration. PLGA films of 
      copolymer ratios of 75:25 and 50:50 were manufactured with thickness levels of 10 
      microm (thin) and 100 microm (thick). Degradation of the films occurred during 
      sample processing, and thin films with a higher surface area to volume ratio 
      degraded faster. Sample weight loss, molecular weight loss, dimensional, and 
      morphological changes were analyzed over a 10-week period of degradation in 0.2 M 
      of phosphate-buffered saline (PBS), pH 7.4, at 37 degrees C. All PLGA films 
      degraded by heterogeneous bulk degradation. Sample weights remained relatively 
      constant for the first several weeks and then decreased dramatically. The 
      molecular weights of PLGA films decreased immediately upon placement in PBS and 
      continued to decrease throughout the time course. PLGA 50:50 films degraded 
      faster than 75:25 films due to their higher content of hydrophilic glycolic 
      units. The results also demonstrated that thick films degrade faster than 
      corresponding thin films with the same composition. This was attributed to the 
      greater extent of the autocatalytic effect, which further was confirmed by 
      heterogeneous gel permeation chromatograms. These studies suggest that the 
      degradation rate of thin films can be engineered by varying film thicknesses.
FAU - Lu, L
AU  - Lu L
AD  - Department of Chemical Engineering, Rice University, Houston, Texas 77005-1892, 
      USA.
FAU - Garcia, C A
AU  - Garcia CA
FAU - Mikos, A G
AU  - Mikos AG
LA  - eng
GR  - R29-AR42639/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Biomed Mater Res
JT  - Journal of biomedical materials research
JID - 0112726
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polymers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Biocompatible Materials/*chemistry
MH  - Chromatography, Gel
MH  - Hydrogen-Ion Concentration
MH  - Lactic Acid/*chemistry
MH  - Microscopy, Electron, Scanning
MH  - Molecular Weight
MH  - Polyglycolic Acid/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/*chemistry
MH  - Surface Properties
EDAT- 1999/06/24 10:00
MHDA- 2000/06/20 09:00
CRDT- 1999/06/24 10:00
PHST- 1999/06/24 10:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/06/24 10:00 [entrez]
AID - 10.1002/(SICI)1097-4636(199908)46:2<236::AID-JBM13>3.0.CO;2-F [pii]
AID - 10.1002/(sici)1097-4636(199908)46:2<236::aid-jbm13>3.0.co;2-f [doi]
PST - ppublish
SO  - J Biomed Mater Res. 1999 Aug;46(2):236-44. doi: 
      10.1002/(sici)1097-4636(199908)46:2<236::aid-jbm13>3.0.co;2-f.