PMID- 10380692
OWN - NLM
STAT- MEDLINE
DCOM- 19990727
LR  - 20221207
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 49
IP  - 6
DP  - 1999 Jun
TI  - Ancestral and recombinant 16-locus HLA haplotypes in the Hutterites.
PG  - 491-7
AB  - Prior studies in the Schmiedeleut Hutterites of South Dakota have demonstrated 
      associations between human leukocyte antigen (HLA) haplotype matching and fetal 
      loss (Ober et al. 1992) and mate preferences (Ober et al. 1997), as well as 
      deficiencies of homozygotes for HLA haplotypes (Kostyu et al. 1993). These 
      studies were based on the serologically-defined five-locus HLA-A, -C, -B, -DR, 
      -DQ haplotype. To further elucidate the effects of specific major 
      histocompatibility (MHC) loci or regions on fetal loss and mate choice, we 
      genotyped a sample of Hutterites for 14 MHC loci by DNA or biochemical methods. 
      Typing for additional loci in the HLA-A to HLA-DPB1 region increased the number 
      of recognized Hutterite MHC haplotypes to 67, and further localized the site of 
      crossover in 9 of 15 recombinant haplotypes. Hutterite MHC haplotype sequences 
      are similar to those observed in outbred Caucasians, suggesting that the 
      influence of HLA haplotypes on fetal loss and mating structure may be general.
FAU - Weitkamp, L R
AU  - Weitkamp LR
AD  - Department of Psychiatry, University of Rochester Medical Center, NY 14642, USA.
FAU - Ober, C
AU  - Ober C
LA  - eng
GR  - R01 HD021244/HD/NICHD NIH HHS/United States
GR  - HD21244/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Chromosome Mapping
MH  - Genealogy and Heraldry
MH  - HLA Antigens/*genetics
MH  - Haplotypes
MH  - Humans
MH  - *Recombination, Genetic
MH  - South Dakota
MH  - White People/*genetics
EDAT- 1999/06/25 00:00
MHDA- 1999/06/25 00:01
CRDT- 1999/06/25 00:00
PHST- 1999/06/25 00:00 [pubmed]
PHST- 1999/06/25 00:01 [medline]
PHST- 1999/06/25 00:00 [entrez]
AID - 10.1007/s002510050525 [doi]
PST - ppublish
SO  - Immunogenetics. 1999 Jun;49(6):491-7. doi: 10.1007/s002510050525.