PMID- 10380839
OWN - NLM
STAT- MEDLINE
DCOM- 19990629
LR  - 20190910
IS  - 0300-9742 (Print)
IS  - 0300-9742 (Linking)
VI  - 28
IP  - 3
DP  - 1999
TI  - Relationship between CD4+/CD8+ T cell ratio and T cell activation in systemic 
      lupus erythematosus.
PG  - 166-70
AB  - We investigated the relationship between the ratio of CD4+ to CD8+ T cells 
      (CD4/CD8 ratio) and T cell activation, indicated by human leukocyte antigen 
      (HLA)-DR expression, in patients with systemic lupus erythematosus (SLE). We 
      found that the ratio was decreased in SLE patients and that this was 
      significantly related to expression of HLA-DR by CD8+ (but not CD4+) T cells. 
      These findings may assist in understanding the pathogenesis of SLE. In some SLE 
      patients, the CD4/CD8 ratio and HLA-DR expression may be good indicators of 
      therapeutic efficacy.
FAU - Maeda, N
AU  - Maeda N
AD  - Department of Medicine, Juntendo University Izu-Nagaoka Hospital, Shizuoka, 
      Japan.
FAU - Sekigawa, I
AU  - Sekigawa I
FAU - Iida, N
AU  - Iida N
FAU - Matsumoto, M
AU  - Matsumoto M
FAU - Hashimoto, H
AU  - Hashimoto H
FAU - Hirose, S
AU  - Hirose S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Scand J Rheumatol
JT  - Scandinavian journal of rheumatology
JID - 0321213
RN  - 0 (HLA-DR Antigens)
RN  - 83HN0GTJ6D (Cyclosporine)
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
MH  - Adult
MH  - *CD4-CD8 Ratio
MH  - Colonic Diseases/drug therapy
MH  - Cyclosporine/therapeutic use
MH  - Female
MH  - HLA-DR Antigens/biosynthesis
MH  - Humans
MH  - Interphase/physiology
MH  - Lupus Erythematosus, Systemic/*blood
MH  - Lymphocyte Activation
MH  - Male
MH  - Middle Aged
MH  - Prednisolone/therapeutic use
MH  - Severity of Illness Index
MH  - T-Lymphocytes/*immunology
MH  - Ulcer/drug therapy
EDAT- 1999/06/25 00:00
MHDA- 1999/06/25 00:01
CRDT- 1999/06/25 00:00
PHST- 1999/06/25 00:00 [pubmed]
PHST- 1999/06/25 00:01 [medline]
PHST- 1999/06/25 00:00 [entrez]
AID - 10.1080/03009749950154248 [doi]
PST - ppublish
SO  - Scand J Rheumatol. 1999;28(3):166-70. doi: 10.1080/03009749950154248.