PMID- 10380967 OWN - NLM STAT- MEDLINE DCOM- 19990916 LR - 20190718 IS - 0959-4965 (Print) IS - 0959-4965 (Linking) VI - 10 IP - 7 DP - 1999 May 14 TI - An antisense oligonucleotide to brain-derived neurotrophic factor delays postural compensation following unilateral labyrinthectomy in guinea pig. PG - 1485-8 AB - An antisense oligonucleotide to brain-derived neurotrophic factor (BDNF) was delivered by osmotic mini-pump at a 1 mM concentration via a cannula into the ipsilateral vestibular nucleus complex from 15 to 56h following unilateral labyrinthectomy in guinea pigs. Compared with the control groups, vestibular compensation of roll head tilt was significantly delayed (p < 0.05), while compensation of spontaneous nystagmus and yaw head tilt was unaffected. These results suggest that neurotrophins such as BDNF may be involved in specific aspects of the vestibular compensation process. FAU - Bolger, C AU - Bolger C AD - Department of Pharmacology, School of Medical Sciences, University of Otago Medical School, Dunedin, New Zealand. FAU - Sansom, A J AU - Sansom AJ FAU - Smith, P F AU - Smith PF FAU - Darlington, C L AU - Darlington CL LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Neuroreport JT - Neuroreport JID - 9100935 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Oligonucleotides, Antisense) SB - IM MH - *Adaptation, Physiological MH - Animals MH - Brain-Derived Neurotrophic Factor/*genetics MH - Ear, Inner/*surgery MH - Female MH - Functional Laterality/*physiology MH - Guinea Pigs MH - Male MH - Oligonucleotides, Antisense/*pharmacology MH - Posture/*physiology MH - Vestibular Nuclei EDAT- 1999/06/25 00:00 MHDA- 1999/06/25 00:01 CRDT- 1999/06/25 00:00 PHST- 1999/06/25 00:00 [pubmed] PHST- 1999/06/25 00:01 [medline] PHST- 1999/06/25 00:00 [entrez] AID - 10.1097/00001756-199905140-00017 [doi] PST - ppublish SO - Neuroreport. 1999 May 14;10(7):1485-8. doi: 10.1097/00001756-199905140-00017.