PMID- 10381186
OWN - NLM
STAT- MEDLINE
DCOM- 19990909
LR  - 20190826
IS  - 0891-5849 (Print)
IS  - 0891-5849 (Linking)
VI  - 26
IP  - 9-10
DP  - 1999 May
TI  - L-carnitine attenuates doxorubicin-induced lipid peroxidation in rats.
PG  - 1158-65
AB  - Doxorubicin (DOX) was administered intraperitoneally to rats in six equal, 2.5 
      mg/kg doses over a 2-week period with or without L-carnitine. Injury was 
      monitored by echocardiography, release of myosin light chain-1 (MLC-1), and by 
      measurement of aldehydic lipid peroxidation products. General observation 
      revealed that DOX alone caused more ascites than DOX plus L-carnitine. Animals 
      sacrificed 2 h after the sixth dose had significantly higher aldehyde 
      concentrations than 2 h after a single dose of DOX. Aldehydes in plasma and heart 
      remained elevated for 3 weeks after the final dose of DOX, whereas L-carnitine 
      prevented or attenuated the DOX-induced increases in lipid peroxidation. The 
      increase in MLC-1 2 h after the sixth dose of DOX was greater than after a single 
      dose, suggesting cumulative damage. Echocardiography did not detect either early 
      injury or the protective effects of L-carnitine. These data indicate that lipid 
      peroxidation following DOX occurs early, and parallels the cumulative 
      characteristics of DOX-induced cardiotoxicity. The protective effects of 
      L-carnitine may be due to improved cardiac energy metabolism and reduced lipid 
      peroxidation.
FAU - Luo, X
AU  - Luo X
AD  - Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, 
      Toronto, Ontario, Canada.
FAU - Reichetzer, B
AU  - Reichetzer B
FAU - Trines, J
AU  - Trines J
FAU - Benson, L N
AU  - Benson LN
FAU - Lehotay, D C
AU  - Lehotay DC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Free Radic Biol Med
JT  - Free radical biology & medicine
JID - 8709159
RN  - 0 (Aldehydes)
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Myosin Light Chains)
RN  - 80168379AG (Doxorubicin)
RN  - S7UI8SM58A (Carnitine)
SB  - IM
MH  - Aldehydes/blood/metabolism
MH  - Animals
MH  - Antibiotics, Antineoplastic/administration & dosage/*antagonists & 
      inhibitors/*toxicity
MH  - Carnitine/administration & dosage/*pharmacology
MH  - Doxorubicin/administration & dosage/*antagonists & inhibitors/*toxicity
MH  - Echocardiography
MH  - Heart/drug effects/physiopathology
MH  - Lipid Peroxidation/*drug effects
MH  - Male
MH  - Myocardial Contraction/drug effects
MH  - Myocardium/metabolism
MH  - Myosin Light Chains/metabolism
MH  - Rats
MH  - Rats, Wistar
EDAT- 1999/06/25 00:00
MHDA- 1999/06/25 00:01
CRDT- 1999/06/25 00:00
PHST- 1999/06/25 00:00 [pubmed]
PHST- 1999/06/25 00:01 [medline]
PHST- 1999/06/25 00:00 [entrez]
AID - S0891-5849(98)00303-7 [pii]
AID - 10.1016/s0891-5849(98)00303-7 [doi]
PST - ppublish
SO  - Free Radic Biol Med. 1999 May;26(9-10):1158-65. doi: 
      10.1016/s0891-5849(98)00303-7.