PMID- 10382864
OWN - NLM
STAT- MEDLINE
DCOM- 19990727
LR  - 20190826
IS  - 0306-3623 (Print)
IS  - 0306-3623 (Linking)
VI  - 32
IP  - 5
DP  - 1999 May
TI  - Salviae radix root extract inhibits immunoglobulin E-mediated allergic reaction.
PG  - 603-8
AB  - We investigated the effects of the aqueous extract of Salviae radix root (SRRAE) 
      on immediate allergic reactions. SRRAE inhibited by 72.7% passive cutaneous 
      anaphylaxis activated by anti-dinitrophenyl (DNP) immunoglobulin E (IgE). SRRAE 
      dose dependently inhibited histamine release and tumor necrosis factor-alpha 
      production from the rat peritoneal mast cells (RPMCs) by anti-DNP IgE. However, 
      SRRAE showed no significant inhibitory effect on compound 48/80-induced systemic 
      allergic reaction and histamine release from RPMCs. The level of cAMP in RPMCs, 
      when SRRAE was added, significantly increased compared with that of a normal 
      control. These results indicate that SRRAE may contain compounds with actions 
      that inhibit anti-DNP IgE-induced mast cell degranulation in rats.
FAU - Kim, H M
AU  - Kim HM
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, 
      Chonbuk, South Korea. hmkim@med.wonkwang.ac.kr
FAU - Lee, E H
AU  - Lee EH
FAU - Lee, J H
AU  - Lee JH
FAU - Jung, J A
AU  - Jung JA
FAU - Kim, J J
AU  - Kim JJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Gen Pharmacol
JT  - General pharmacology
JID - 7602417
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 820484N8I3 (Histamine)
RN  - E0399OZS9N (Cyclic AMP)
SB  - IM
MH  - Anaphylaxis/chemically induced/prevention & control
MH  - Animals
MH  - Cyclic AMP/metabolism
MH  - Histamine/metabolism
MH  - Hypersensitivity/immunology/*prevention & control
MH  - Immunoglobulin E
MH  - Magnoliopsida/*chemistry
MH  - Mast Cells/drug effects/*metabolism
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - Phytotherapy
MH  - Plant Extracts/pharmacology/*therapeutic use
MH  - Plant Roots/chemistry
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - p-Methoxy-N-methylphenethylamine/pharmacology
EDAT- 1999/06/26 00:00
MHDA- 1999/06/26 00:01
CRDT- 1999/06/26 00:00
PHST- 1999/06/26 00:00 [pubmed]
PHST- 1999/06/26 00:01 [medline]
PHST- 1999/06/26 00:00 [entrez]
AID - S0306362398002262 [pii]
AID - 10.1016/s0306-3623(98)00226-2 [doi]
PST - ppublish
SO  - Gen Pharmacol. 1999 May;32(5):603-8. doi: 10.1016/s0306-3623(98)00226-2.