PMID- 10383115
OWN - NLM
STAT- MEDLINE
DCOM- 19990729
LR  - 20081121
IS  - 1059-910X (Print)
IS  - 1059-910X (Linking)
VI  - 45
IP  - 4-5
DP  - 1999 May 15-Jun 1
TI  - Classical and novel directions in neurotrophin transport and research: 
      anterograde transport of brain-derived neurotrophic factor by sensory neurons.
PG  - 225-32
AB  - After the discovery of nerve growth factor, a classic model of neurotrophin 
      action was developed. In this model, nerve endings compete for limited quantities 
      of neurotrophic factors produced in neuronal target tissues. Neurotrophins are 
      bound with high-affinity receptors expressed on the neuronal membrane and then 
      endocytosed and retrogradely transported back to the cell body of responsive 
      neurons. This classic model of target derived trophic support has been utilized 
      to explain a wide range of trophic actions including effects on neuronal 
      survival, terminal branching, and protein expression. However, a number of recent 
      findings in the field of neurotrophin research cannot be explained using the 
      classic model. In the peripheral nervous system (PNS), sensory neurons have been 
      shown to contain mRNA for a member of the neurotrophin family, brain-derived 
      neurotrophic factor (BDNF). Sensory neurons do not receive synaptic input so 
      neurotrophin production by these cells does not fit into the classic target 
      derived model. In contrast to target derived trophic support, BDNF produced by 
      sensory neurons provides local autocrine and paracrine neurotrophic support in 
      vitro. Furthermore, in vivo, sensory neurons transport BDNF in the anterograde 
      direction away from the cell body, and opposite to the retrograde direction 
      utilized in the classic model. Thus, out of necessity, a new direction for 
      neurotrophin research has developed to study the production and anterograde 
      transport of neurotrophins. The importance of this new mode of neurotrophin 
      action in the PNS is indicated by results that implicate it in the response to 
      pain, inflammation, and nerve injury.
FAU - Tonra, J R
AU  - Tonra JR
AD  - Millennium BioTherapeutics, Cambridge, Massachusetts 02139, USA.
LA  - eng
GR  - P01-NS14899/NS/NINDS NIH HHS/United States
GR  - R01-NS16996/NS/NINDS NIH HHS/United States
GR  - R01-NS32264/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Microsc Res Tech
JT  - Microscopy research and technique
JID - 9203012
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Brain Chemistry/*physiology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Inflammation/metabolism
MH  - Nerve Crush
MH  - Nerve Growth Factors/metabolism
MH  - Neurons, Afferent/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Sensory Receptor Cells/metabolism
RF  - 122
EDAT- 1999/06/26 10:00
MHDA- 2000/06/22 10:00
CRDT- 1999/06/26 10:00
PHST- 1999/06/26 10:00 [pubmed]
PHST- 2000/06/22 10:00 [medline]
PHST- 1999/06/26 10:00 [entrez]
AID - 10.1002/(SICI)1097-0029(19990515/01)45:4/5<225::AID-JEMT6>3.0.CO;2-1 [pii]
AID - 10.1002/(SICI)1097-0029(19990515/01)45:4/5<225::AID-JEMT6>3.0.CO;2-1 [doi]
PST - ppublish
SO  - Microsc Res Tech. 1999 May 15-Jun 1;45(4-5):225-32. doi: 
      10.1002/(SICI)1097-0029(19990515/01)45:4/5<225::AID-JEMT6>3.0.CO;2-1.