PMID- 10383614
OWN - NLM
STAT- MEDLINE
DCOM- 19990730
LR  - 20190815
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 11
IP  - 7
DP  - 1999 Jul
TI  - Regionalization of Fos immunostaining in rat accessory olfactory bulb when the 
      vomeronasal organ was exposed to urine.
PG  - 2254-60
AB  - The distribution of Fos-immunoreactive (Fos-ir) cells in the accessory olfactory 
      bulb (AOB) of rats following vomeronasal organ exposure to urine was studied. 
      Following exposure to male and female Wistar rat urine, Fos-ir cells were found 
      in the mitral/tufted cell layer, granule cell layer and periglomerular cell layer 
      of the AOB of female Wistar rat, with the highest number in the granule cell 
      layer. Exposure to water or removal of the vomeronasal organ suppressed the 
      expression of Fos-ir cells. These results suggest that female Wistar rats 
      specifically detect urinary substances derived from male or female Wistar rats 
      via the vomeronasal organ. Exposure of the vomeronasal organ of female Wistar 
      rats to male Wistar urine induced the appearance of many more Fos-ir cells in all 
      layers of the AOB than exposure to female Wistar urine. As for the mitral/tufted 
      cell layer, the density of Fos-ir cells in the rostral portion 
      (Gi2alpha-positive) of all regions of the AOB was about twice as high as that in 
      the caudal portion when male urine was given. The distribution pattern of Fos-ir 
      cells in response to female urine was not identical to that in response to male 
      urine. That is, the density of Fos-ir cells in the caudal portion was slightly 
      larger than that in the rostral portion in the lateral region, while in other 
      regions the density in the rostral portion was higher than that in the caudal 
      portion. It is likely that information from different pheromones is transmitted 
      to the higher brain regions through the different regions of the AOB.
FAU - Inamura, K
AU  - Inamura K
AD  - Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 
      060-0812, Japan.
FAU - Kashiwayanagi, M
AU  - Kashiwayanagi M
FAU - Kurihara, K
AU  - Kurihara K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Proto-Oncogene Proteins c-fos)
SB  - IM
MH  - Animals
MH  - Female
MH  - Immunohistochemistry
MH  - Male
MH  - Olfactory Bulb/*metabolism
MH  - Proto-Oncogene Proteins c-fos/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Sex Characteristics
MH  - Urine/*physiology
MH  - Vomeronasal Organ/*physiology
EDAT- 1999/06/26 00:00
MHDA- 1999/06/26 00:01
CRDT- 1999/06/26 00:00
PHST- 1999/06/26 00:00 [pubmed]
PHST- 1999/06/26 00:01 [medline]
PHST- 1999/06/26 00:00 [entrez]
AID - ejn646 [pii]
AID - 10.1046/j.1460-9568.1999.00646.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 1999 Jul;11(7):2254-60. doi: 10.1046/j.1460-9568.1999.00646.x.