PMID- 10384950
OWN - NLM
STAT- MEDLINE
DCOM- 19990826
LR  - 20191024
IS  - 0301-634X (Print)
IS  - 0301-634X (Linking)
VI  - 38
IP  - 1
DP  - 1999 May
TI  - Modelling radiation-induced biological lesions: from initial energy depositions 
      to chromosome aberrations.
PG  - 1-13
AB  - The development of biophysical models of chromosome aberration induction has 
      undergone considerable improvements in the past few years. This is mainly due to 
      the development of new experimental techniques, such as fluorescence in situ 
      hybridization (FISH) and premature chromosome condensation (PCC), and to a better 
      knowledge of track structure characteristics (both in the physical and chemical 
      stages). In particular, track structure simulations, providing a detailed 
      description of the spatial distribution of energy depositions and relevant DNA 
      lesions, represent a useful starting point for the development of 'ab initio' 
      models. Various aspects of the processes determining the induction and the 
      formation kinetics of chromosome aberrations are still under debate, concerning 
      in particular the target description (interphase chromosome organization), the 
      characterization of relevant DNA lesions, the possibility of inducing exchanges 
      starting from single radiation-induced lesions, the rejoining mechanisms 
      (proximity effects and possible induction of incomplete exchanges, i.e. one-way 
      exchanges) and the influence of specific scoring criteria adopted both in 
      experiments and models. Starting from Lea's breakage-and-reunion theory and 
      Revell's exchange theory, an overview is given of various models recently 
      reported in the literature. The assumptions adopted by the authors concerning the 
      various processes involved in aberration formation are analysed in detail, in 
      order to clarify the different approaches adopted in treating the open questions 
      outlined above.
FAU - Ottolenghi, A
AU  - Ottolenghi A
AD  - Dipartimento di Fisica, Universita di Milano and INFN-sezione di Milano, Milan, 
      Italy. Andrea.Ottolenghi@mi.infn.it
FAU - Ballarini, F
AU  - Ballarini F
FAU - Merzagora, M
AU  - Merzagora M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Germany
TA  - Radiat Environ Biophys
JT  - Radiation and environmental biophysics
JID - 0415677
SB  - IM
MH  - Algorithms
MH  - Animals
MH  - *Chromosome Aberrations
MH  - *Disease Models, Animal
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Radiation Injuries, Experimental/*genetics
MH  - Radiobiology/*methods
RF  - 76
EDAT- 1999/06/29 00:00
MHDA- 1999/06/29 00:01
CRDT- 1999/06/29 00:00
PHST- 1999/06/29 00:00 [pubmed]
PHST- 1999/06/29 00:01 [medline]
PHST- 1999/06/29 00:00 [entrez]
AID - 10.1007/s004110050132 [doi]
PST - ppublish
SO  - Radiat Environ Biophys. 1999 May;38(1):1-13. doi: 10.1007/s004110050132.