PMID- 10386163
OWN - NLM
STAT- MEDLINE
DCOM- 19990914
LR  - 20061115
IS  - 0367-6102 (Print)
IS  - 0367-6102 (Linking)
VI  - 74
IP  - 2
DP  - 1999 Mar
TI  - Analysis of matrix metalloproteinases and related tissue inhibitors in cystic 
      fluids of ovarian tumors.
PG  - 145-55
AB  - Proteolytic activity of cystic neoplasms of the ovary appears to play a role in 
      destruction of the extracellular matrix and tumor invasion. The purpose of this 
      study was to determine whether the enzymatic activities reflect the degrees of 
      tumor malignancy. The author examined the activity and quantity of matrix 
      metalloproteinases (MMPs) and tissue inhibitors of MMP (TIMPs) in cystic fluids 
      of both benign and malignant epithelial ovarian tumors. The concentration of 
      MMP-9 was statistically higher in mucinous carcinomas (p < 0.05) than in benign 
      ones. TIMP-1, which combines with MMP-9, was also higher (p < 0.05) in 
      malignancies than in benign ones. The ratios of MMP-9/MMP-2 and the 
      concentrations of activated forms of MMPs well associated with the degrees of 
      malignancy, while the mol ratios of TIMP-1/MMP-9 and TIMP-2/MMP-2 inversely 
      correlated. Expressions of MMP-3 and/or trypsin in the fluids were frequently 
      associated with activation of MMP-7 and MMP-9. These observations support the 
      concept that the imbalance of TIMPs/MMPs and the activation of MMPs correlate 
      with the biological malignancy of ovarian cystic tumors.
FAU - Furuya, M
AU  - Furuya M
AD  - Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, 
      Sapporo, Japan.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Hokkaido Igaku Zasshi
JT  - [Hokkaido igaku zasshi] The Hokkaido journal of medical science
JID - 17410290R
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - EC 3.4.24.- (Collagenases)
RN  - EC 3.4.24.- (Metalloendopeptidases)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Adenoma/*enzymology/pathology
MH  - Carcinoma/*enzymology/pathology
MH  - Collagenases/analysis
MH  - Female
MH  - Humans
MH  - Matrix Metalloproteinase 3/analysis
MH  - Matrix Metalloproteinase 9
MH  - Metalloendopeptidases/*analysis
MH  - Neoplasm Staging
MH  - Ovarian Neoplasms/*enzymology/pathology
MH  - Tissue Inhibitor of Metalloproteinases/*analysis
MH  - Tumor Cells, Cultured
EDAT- 1999/07/01 00:00
MHDA- 1999/07/01 00:01
CRDT- 1999/07/01 00:00
PHST- 1999/07/01 00:00 [pubmed]
PHST- 1999/07/01 00:01 [medline]
PHST- 1999/07/01 00:00 [entrez]
PST - ppublish
SO  - Hokkaido Igaku Zasshi. 1999 Mar;74(2):145-55.