PMID- 10386472
OWN - NLM
STAT- MEDLINE
DCOM- 19990708
LR  - 20220318
IS  - 0270-4137 (Print)
IS  - 0270-4137 (Linking)
VI  - 40
IP  - 2
DP  - 1999 Jul 1
TI  - Estrogen receptor-beta: implications for the prostate gland.
PG  - 115-24
AB  - Estrogens can have profound effects on prostate growth and differentiation. These 
      effects were thought to be mediated by the classical estrogen receptor; however, 
      the discovery of a second estrogen receptor has redefined the estrogen signaling 
      pathway and may have broad implications on estrogen-responsive tissues, including 
      the prostate. The new estrogen receptor, named estrogen receptor-beta (ERbeta), 
      is preferentially expressed in the prostate and maintains some characteristics 
      that are different from ERalpha. Establishing the distribution and function of 
      ERbeta in the various estrogen-responsive tissues is critical to defining its 
      pharmacological and physiological impact. Differential expression of ERbeta may 
      facilitate development of tissue-specific estrogen agonists and antagonists, a 
      goal in the treatment of diseases in estrogen-sensitive tissues such as breast 
      cancer. This article reviews the current knowledge on ERbeta and its potential 
      impact on the prostate.
FAU - Chang, W Y
AU  - Chang WY
AD  - Department of Urology, University of Illinois College of Medicine, Chicago 60612, 
      USA.
FAU - Prins, G S
AU  - Prins GS
LA  - eng
GR  - R01 DK040890/DK/NIDDK NIH HHS/United States
GR  - DK-09873/DK/NIDDK NIH HHS/United States
GR  - DK-40890/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Prostate
JT  - The Prostate
JID - 8101368
RN  - 0 (Receptors, Estrogen)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Binding Sites
MH  - DNA/metabolism
MH  - Dimerization
MH  - Humans
MH  - Male
MH  - *Prostate/chemistry/cytology/physiology
MH  - *Receptors, Estrogen/chemistry/metabolism/physiology
MH  - Transcriptional Activation
RF  - 63
EDAT- 1999/07/01 10:00
MHDA- 2000/06/20 09:00
CRDT- 1999/07/01 10:00
PHST- 1999/07/01 10:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/07/01 10:00 [entrez]
AID - 10.1002/(SICI)1097-0045(19990701)40:2<115::AID-PROS7>3.0.CO;2-3 [pii]
AID - 10.1002/(sici)1097-0045(19990701)40:2<115::aid-pros7>3.0.co;2-3 [doi]
PST - ppublish
SO  - Prostate. 1999 Jul 1;40(2):115-24. doi: 
      10.1002/(sici)1097-0045(19990701)40:2<115::aid-pros7>3.0.co;2-3.