PMID- 10390145
OWN - NLM
STAT- MEDLINE
DCOM- 19990715
LR  - 20191104
IS  - 0262-0898 (Print)
IS  - 0262-0898 (Linking)
VI  - 17
IP  - 1
DP  - 1999 Feb
TI  - Inhibitory effects of bovine lactoferrin on colon carcinoma 26 lung metastasis in 
      mice.
PG  - 35-40
AB  - In order to determine the effects of the multifunctional iron-binding 
      glycoprotein, lactoferrin (LF), and related compounds on tumor growth and 
      metastasis, bovine LF (bLF), and bLF hydrolysate and lactoferricin (bLFcin), 
      active products generated by acid-pepsin hydrolysis were administered orally to 
      BALB/c mice bearing subcutaneous (s.c.) implants of the highly metastatic colon 
      carcinoma 26 (Co 26Lu). bLF and the bLF hydrolysate demonstrated significant 
      inhibition of lung metastatic colony formation from s.c. implanted tumors without 
      appreciable effects on tumor growth. bLFcin displayed a tendency for inhibition 
      of lung metastasis. On the other hand, bLF did not exert marked anti-metastatic 
      activity in athymic nude mice bearing Co 26Lu, though bLF had a tendency to 
      inhibit the lung metastatic colony formation associated with anti-asialoGM1 
      antibody (Ab) treatment. AsialoGM1+ and CD8+ cells in white blood cells were 
      increased after treatment with bLF. In vitro, the viability of Co 26Lu-F55 cells 
      was markedly decreased when co-cultured with white blood cells from mice 
      administrated bLF p.o., but recovered on treatment with anti-asialoGM1 Ab or 
      anti-CD8 mAb and complement. The results suggest bLF and related compounds might 
      find application as tools in the control of metastasis and that asialoGM1+ and 
      CD8+ cells in the blood are important for their inhibitory effects.
FAU - Iigo, M
AU  - Iigo M
AD  - Experimental Pathology and Chemotherapy Division, National Cancer Center Research 
      Institute, Tokyo, Japan.
FAU - Kuhara, T
AU  - Kuhara T
FAU - Ushida, Y
AU  - Ushida Y
FAU - Sekine, K
AU  - Sekine K
FAU - Moore, M A
AU  - Moore MA
FAU - Tsuda, H
AU  - Tsuda H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Clin Exp Metastasis
JT  - Clinical & experimental metastasis
JID - 8409970
RN  - 0 (Antineoplastic Agents)
RN  - 0 (CD4 Antigens)
RN  - 0 (CD8 Antigens)
RN  - EC 3.4.21.- (Lactoferrin)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Antineoplastic Agents/*therapeutic use
MH  - CD4 Antigens/blood
MH  - CD8 Antigens/blood
MH  - Cattle
MH  - Cell Division/drug effects
MH  - Cell Survival/drug effects
MH  - Colonic Neoplasms/*drug therapy
MH  - Drug Screening Assays, Antitumor
MH  - Hydrolysis
MH  - Lactoferrin/blood/*therapeutic use
MH  - Leukocytes/immunology
MH  - Lung Neoplasms/*prevention & control/secondary
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
EDAT- 1999/07/02 00:00
MHDA- 1999/07/02 00:01
CRDT- 1999/07/02 00:00
PHST- 1999/07/02 00:00 [pubmed]
PHST- 1999/07/02 00:01 [medline]
PHST- 1999/07/02 00:00 [entrez]
AID - 10.1023/a:1026452110786 [doi]
PST - ppublish
SO  - Clin Exp Metastasis. 1999 Feb;17(1):35-40. doi: 10.1023/a:1026452110786.