PMID- 10391860
OWN - NLM
STAT- MEDLINE
DCOM- 19990831
LR  - 20210526
IS  - 1071-412X (Print)
IS  - 1098-6588 (Electronic)
IS  - 1071-412X (Linking)
VI  - 6
IP  - 4
DP  - 1999 Jul
TI  - Similar humoral and cellular immunological reactivities to human herpesvirus 6 in 
      patients with multiple sclerosis and controls.
PG  - 545-9
AB  - Several studies have suggested an association between human herpesvirus 6 (HHV-6) 
      and multiple sclerosis (MS). We have previously studied intrathecal production of 
      antibody to lymphotropic herpesviruses in MS patients and the presence of human 
      herpesvirus 1 to 7 DNAs in cerebrospinal fluid (CSF). In the present study 
      anti-HHV-6 immunoglobulin M (IgM) in serum and anti-HHV-6 IgG subclasses in serum 
      and CSF were examined and the lymphoproliferative response to HHV-6 was analyzed. 
      The PCR examination was refined by purifying DNA from CSF and retesting the 
      samples for HHV-6 DNA. There were no statistically significant differences 
      between the groups concerning IgM positivity, distribution of IgG subclasses, or 
      lymphoproliferative response to HHV-6. The purification of DNA increased the 
      number of PCR-positive samples from 0 of 71 to 4 of 68. The study does not give 
      additional support to the possibility that HHV-6 is a common cause of MS, but a 
      role for the virus in a subset of patients cannot be excluded.
FAU - Enbom, M
AU  - Enbom M
AD  - Department of Virology, Swedish Institute for Infectious Disease Control, 
      Stockholm, Sweden. malin_enbom@hotmail.com
FAU - Wang, F Z
AU  - Wang FZ
FAU - Fredrikson, S
AU  - Fredrikson S
FAU - Martin, C
AU  - Martin C
FAU - Dahl, H
AU  - Dahl H
FAU - Linde, A
AU  - Linde A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Diagn Lab Immunol
JT  - Clinical and diagnostic laboratory immunology
JID - 9421292
RN  - 0 (DNA, Viral)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibody Formation
MH  - DNA, Viral/blood/cerebrospinal fluid
MH  - Female
MH  - Herpesvirus 6, Human/genetics/*immunology
MH  - Humans
MH  - Immunity, Cellular
MH  - Immunoglobulin G/blood
MH  - Immunoglobulin M/blood
MH  - Lymphocyte Activation
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/cerebrospinal fluid/genetics/*immunology
MH  - Polymerase Chain Reaction
PMC - PMC95725
EDAT- 1999/07/03 00:00
MHDA- 1999/07/03 00:01
PMCR- 1999/07/01
CRDT- 1999/07/03 00:00
PHST- 1999/07/03 00:00 [pubmed]
PHST- 1999/07/03 00:01 [medline]
PHST- 1999/07/03 00:00 [entrez]
PHST- 1999/07/01 00:00 [pmc-release]
AID - 0020 [pii]
AID - 10.1128/CDLI.6.4.545-549.1999 [doi]
PST - ppublish
SO  - Clin Diagn Lab Immunol. 1999 Jul;6(4):545-9. doi: 10.1128/CDLI.6.4.545-549.1999.