PMID- 10393509
OWN - NLM
STAT- MEDLINE
DCOM- 19991001
LR  - 20171101
IS  - 1018-1172 (Print)
IS  - 1018-1172 (Linking)
VI  - 36
IP  - 3
DP  - 1999 May-Jun
TI  - Evidence for structural alterations in resistance arteries of patients with 
      severe congestive heart failure.
PG  - 229-34
AB  - Congestive heart failure (CHF) is characterized by an increase in total 
      peripheral resistance. It was the specific aim of this study to investigate 
      whether structural factors participate in the increased peripheral resistance 
      that can be observed in severe heart failure. We determined forearm vascular 
      resistance (FVR) at rest and after 10 min ischemia (Rmin; mm Hg/ml/min/100 ml) 
      using venous occlusion plethysmography. Rmin was studied since it is largely 
      dependent on the structural characteristics of resistance arteries. 24 patients 
      with CHF [71.5 +/- 2.3 years; New York Heart Association (NYHA) functional class 
      I-IV] with no history of arterial hypertension and casual arterial blood pressure 
      < 140/90 mm Hg and 24 normotensive healthy control subjects (52.5 +/- 4.1 years) 
      were included in our study. The patients were subdivided into those with 'mild' 
      (NYHA class I and II; n = 10) and 'severe' (NYHA class III and IV; n = 14) heart 
      failure. There were no significant differences between the two groups for 
      echocardiographically determined ejection fraction and mean arterial blood 
      pressure. Resting FVR averaged 40.5 +/- 4.4 mm Hg/ml/min/100 ml in control 
      subjects and was 43.6 +/- 7.9 (nonsignificant vs. control) and 51.0 +/- 5 mm 
      Hg/ml/min/100 ml (p < 0.05 vs. control) in patients with mild and severe CHF, 
      respectively. No significant correlation between age and Rmin could be 
      demonstrated in either the patient or the control group. Furthermore, Rmin did 
      not differ between patients with mild CHF and control subjects. However, Rmin was 
      significantly elevated in patients with severe CHF (5.7 +/- 0.39 mm Hg/ml/min/100 
      ml) as compared to patients with mild CHF (4.0 +/- 0.39 mm Hg/ml/min/100 ml; p < 
      0.05) and controls (4.5 +/- 0.26 mm Hg/ml/min/100 ml; p < 0.05). In conclusion, 
      our study supports the concept that structural alterations contribute to the 
      increased peripheral resistance in patients with heart failure. These changes are 
      correlated with the severity of clinical symptoms.
FAU - Mengden, T
AU  - Mengden T
AD  - Medizinische Universitats-Poliklinik, Bonn, Germany.
FAU - Douven, C
AU  - Douven C
FAU - Vetter, H
AU  - Vetter H
FAU - Dusing, R
AU  - Dusing R
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - J Vasc Res
JT  - Journal of vascular research
JID - 9206092
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging/physiology
MH  - Arteries/physiopathology
MH  - Blood Pressure
MH  - Female
MH  - Forearm/*blood supply
MH  - Heart Failure/*physiopathology
MH  - Hemodynamics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Plethysmography
MH  - *Vascular Resistance
EDAT- 1999/07/07 00:00
MHDA- 1999/07/07 00:01
CRDT- 1999/07/07 00:00
PHST- 1999/07/07 00:00 [pubmed]
PHST- 1999/07/07 00:01 [medline]
PHST- 1999/07/07 00:00 [entrez]
AID - 25646 [pii]
AID - 10.1159/000025646 [doi]
PST - ppublish
SO  - J Vasc Res. 1999 May-Jun;36(3):229-34. doi: 10.1159/000025646.