PMID- 10393979
OWN - NLM
STAT- MEDLINE
DCOM- 19990826
LR  - 20230331
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 14
DP  - 1999 Jul 6
TI  - Estrogen-inducible, sex-specific expression of brain-derived neurotrophic factor 
      mRNA in a forebrain song control nucleus of the juvenile zebra finch.
PG  - 8241-6
AB  - The expression of brain-derived neurotrophic factor (BDNF) mRNA is increased 
      significantly within the high vocal center (HVc) of male but not female zebra 
      finches from posthatching day 30-35 on. The population of HVc cells expressing 
      BDNF mRNA included 35% of the neurons projecting to the nucleus robustus of the 
      archistriatum (RA). In the RA and in RA-projecting neurons of the lateral portion 
      of the magnocellular nucleus of the anterior neostriatum, BDNF mRNA was expressed 
      at very low levels in both sexes. The BDNF-receptor trkB mRNA was expressed in 
      the RA, in RA-projecting neurons of lateral portion of the magnocellular nucleus 
      of the anterior neostriatum, and in the HVc, except in most of its RA-projecting 
      neurons. Premature stimulation and an inhibitory effect on the normal increase of 
      the BDNF mRNA expression in juvenile males occurred after treatments with 
      17beta-estradiol and the aromatase inhibitor fadrozole, respectively. The 
      up-regulation of the BDNF expression in the HVc could be a mechanism by which 
      estrogen triggers the differentiation of cells within and connected to the HVc of 
      male zebra finches.
FAU - Dittrich, F
AU  - Dittrich F
AD  - Max-Planck-Institut fur Verhaltensphysiologie, D-82319 Seewiesen, Germany; and 
      Faculteit der Biologie, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands. 
      dittrich@bio.vu.nl
FAU - Feng, Y
AU  - Feng Y
FAU - Metzdorf, R
AU  - Metzdorf R
FAU - Gahr, M
AU  - Gahr M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Aromatase Inhibitors)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Drug Implants)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptor, Ciliary Neurotrophic Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 4TI98Z838E (Estradiol)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - H3988M64PU (Fadrozole)
SB  - IM
MH  - Animals
MH  - Aromatase Inhibitors
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Drug Implants
MH  - Estradiol/administration & dosage/*pharmacology
MH  - Fadrozole/pharmacology
MH  - Female
MH  - Hippocampus/drug effects/metabolism
MH  - In Situ Hybridization
MH  - Male
MH  - Neurons/cytology/drug effects/*metabolism
MH  - Prosencephalon/drug effects/*metabolism
MH  - RNA, Messenger/genetics
MH  - Receptor Protein-Tyrosine Kinases/*genetics
MH  - Receptor, Ciliary Neurotrophic Factor
MH  - Receptors, Nerve Growth Factor/*genetics
MH  - Sex Characteristics
MH  - Songbirds/*physiology
MH  - Transcription, Genetic/drug effects/*physiology
MH  - Vocalization, Animal/*physiology
PMC - PMC22219
EDAT- 1999/07/08 00:00
MHDA- 1999/07/08 00:01
PMCR- 2000/01/06
CRDT- 1999/07/08 00:00
PHST- 1999/07/08 00:00 [pubmed]
PHST- 1999/07/08 00:01 [medline]
PHST- 1999/07/08 00:00 [entrez]
PHST- 2000/01/06 00:00 [pmc-release]
AID - 2860 [pii]
AID - 10.1073/pnas.96.14.8241 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8241-6. doi: 10.1073/pnas.96.14.8241.