PMID- 10394458
OWN - NLM
STAT- MEDLINE
DCOM- 19990803
LR  - 20190831
IS  - 0929-693X (Print)
IS  - 0929-693X (Linking)
VI  - 6
IP  - 6
DP  - 1999 Jun
TI  - [Proton pump inhibitors in pediatrics].
PG  - 650-6
AB  - For the past ten years or so, proton pump inhibitors (PPI) such as omeprazole, 
      lansoprazole, or pantoprazole, have become the reference treatment for peptic 
      disorders in adults. PPIs have recently begun to be used in pediatrics, and this 
      use is likely to expand. They act on the final step of gastric acid secretion by 
      completely inhibiting the ATPase (proton pump) at the surface of the gastric 
      parietal cells, thus yielding long term inhibition which is not correlated with 
      the plasma concentration of the drug, in contrast to the effects of H2-blocker 
      drugs. Our knowledge of this new class of treatment in pediatrics is still 
      fragmentary, but the reported pharmacokinetic and clinical data indicate that 
      they are suitable for use in children. While the short-term risk of complications 
      appears to be minimal, the tolerance of these drugs in chronic use requires 
      careful monitoring because of the potential consequences of prolonged inhibition 
      of acid secretion.
FAU - Faure, C
AU  - Faure C
AD  - Service de gastroenterologie pediatrique, hopital Robert-Debre, Paris, France.
FAU - Pelatan, C
AU  - Pelatan C
FAU - Languepin, J
AU  - Languepin J
LA  - fre
PT  - Journal Article
PT  - Review
TT  - Inhibiteurs de la pompe a protons en pediatrie.
PL  - France
TA  - Arch Pediatr
JT  - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
JID - 9421356
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Benzimidazoles)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0 (Sulfoxides)
RN  - 0K5C5T2QPG (Lansoprazole)
RN  - D8TST4O562 (Pantoprazole)
RN  - EC 3.6.3.14 (Proton-Translocating ATPases)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles
MH  - Adult
MH  - Anti-Ulcer Agents/*therapeutic use
MH  - Benzimidazoles/therapeutic use
MH  - Child
MH  - Enzyme Inhibitors/*therapeutic use
MH  - Humans
MH  - Lansoprazole
MH  - Omeprazole/analogs & derivatives/therapeutic use
MH  - Pantoprazole
MH  - Peptic Ulcer/*drug therapy
MH  - Proton Pump Inhibitors
MH  - Proton-Translocating ATPases/*antagonists & inhibitors
MH  - Sulfoxides/therapeutic use
RF  - 30
EDAT- 1999/07/08 10:00
MHDA- 2000/05/05 09:00
CRDT- 1999/07/08 10:00
PHST- 1999/07/08 10:00 [pubmed]
PHST- 2000/05/05 09:00 [medline]
PHST- 1999/07/08 10:00 [entrez]
AID - S0929693X9980298X [pii]
AID - 10.1016/s0929-693x(99)80298-x [doi]
PST - ppublish
SO  - Arch Pediatr. 1999 Jun;6(6):650-6. doi: 10.1016/s0929-693x(99)80298-x.