PMID- 10395412
OWN - NLM
STAT- MEDLINE
DCOM- 19990817
LR  - 20190831
IS  - 0167-0115 (Print)
IS  - 0167-0115 (Linking)
VI  - 81
IP  - 1-3
DP  - 1999 May 31
TI  - Cardiorespiratory responses to intracerebroventricular injection of neuropeptide 
      Y in anaesthetised dogs.
PG  - 81-8
AB  - Cardiovascular and respiratory effects of intracerebroventricular (icv) 
      administration of neuropeptide Y (NPY) and separate, preferential agonists for 
      NPY Y1 and Y2 receptors were observed in anaesthetised dogs. Central injections 
      of NPY resulted in significant cardiac slowing and decreases in arterial 
      pressure. These cardiovascular effects were blocked by central injection of the 
      NPY Y1- preferring antagonist 1229U91. Central injection of NPY did not have a 
      significant effect on ventilation, but the NPY Y1 antagonist 1229U91 administered 
      alone caused a significant increase in ventilation. The NPY Y1-receptor agonist 
      [Leu31Pro34] NPY significantly decreased ventilation while the NPY Y2 receptor 
      agonist N-acetyl [Leu28Leu31] NPY 24--36 significantly increased it. A similar 
      inverse relationship was seen with respect to blood pressure, with the NPY 
      Y1-receptor agonist [Leu31Pro34] NPY significantly decreasing blood pressure, 
      while the NPY Y2 receptor agonist N-acetyl [Leu28Leu31] NPY 24-36 significantly 
      increased it. These findings suggest a role for NPY Y1 receptors in pathways 
      mediating decreases in ventilation and blood pressure, and for NPY Y2 receptors 
      in those mediating increased ventilation and blood pressure.
FAU - Morton, K D
AU  - Morton KD
AD  - Prince of Wales Medical Research Institute, Sydney, New South Wales, Australia. 
      k.morton@unsw.edu.au
FAU - McCloskey, M J
AU  - McCloskey MJ
FAU - Potter, E K
AU  - Potter EK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Regul Pept
JT  - Regulatory peptides
JID - 8100479
RN  - 0 (1229U91)
RN  - 0 (Neuropeptide Y)
RN  - 0 (Peptide Fragments)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (Receptors, Neuropeptide Y)
RN  - 0 (neuropeptide Y (24-36), Ac-(Leu(28,31))-)
RN  - 0 (neuropeptide Y2 receptor)
RN  - 125580-28-1 (neuropeptide Y, Leu(31)-Pro(34)-)
SB  - IM
MH  - Anesthesia
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Dogs
MH  - Female
MH  - Heart Rate/*drug effects
MH  - Injections, Intraventricular
MH  - Male
MH  - Neuropeptide Y/analogs & derivatives/antagonists & inhibitors/*pharmacology
MH  - Peptide Fragments/pharmacology
MH  - Peptides, Cyclic/pharmacology
MH  - Receptors, Neuropeptide Y/agonists
MH  - Respiration/*drug effects
MH  - Ventilation
EDAT- 1999/07/08 00:00
MHDA- 1999/07/08 00:01
CRDT- 1999/07/08 00:00
PHST- 1999/07/08 00:00 [pubmed]
PHST- 1999/07/08 00:01 [medline]
PHST- 1999/07/08 00:00 [entrez]
AID - S0167-0115(99)00021-X [pii]
AID - 10.1016/s0167-0115(99)00021-x [doi]
PST - ppublish
SO  - Regul Pept. 1999 May 31;81(1-3):81-8. doi: 10.1016/s0167-0115(99)00021-x.