PMID- 10395793 OWN - NLM STAT- MEDLINE DCOM- 19990830 LR - 20071114 IS - 0888-7543 (Print) IS - 0888-7543 (Linking) VI - 59 IP - 1 DP - 1999 Jul 1 TI - Integration of cytogenetic with recombinational and physical maps of mouse chromosome 16. PG - 1-5 AB - To link the cytogenetic map for mouse chromosome 16 (Chr 16) to the more detailed recombinational and physical maps, multiple probes were mapped by fluorescence in situ hybridization (FISH). Sixteen large insert clones (YACs, BACs, and PACs) containing markers that have been assigned to the Chr 16 recombinational map were localized to a cytogenetic band or subband by high-resolution FISH. This linkage of the cytogenetic and recombinational maps provides a useful tool for assigning new probe locations and for defining breakpoints in mice with chromosomal rearrangements. A direct application of these probes is demonstrated by identifying mice trisomic for distal Chr 16 using FISH analysis of interphase nuclei. CI - Copyright 1999 Academic Press. FAU - Moore, C S AU - Moore CS AD - Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. FAU - Lee, J S AU - Lee JS FAU - Birren, B AU - Birren B FAU - Stetten, G AU - Stetten G FAU - Baxter, L L AU - Baxter LL FAU - Reeves, R H AU - Reeves RH LA - eng GR - HD24605/HD/NICHD NIH HHS/United States GR - HG00405/HG/NHGRI NIH HHS/United States GR - HG00934/HG/NHGRI NIH HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Genomics JT - Genomics JID - 8800135 RN - 0 (Genetic Markers) SB - IM MH - Animals MH - Chromosome Mapping/*methods MH - Chromosomes/*genetics MH - Chromosomes, Human/genetics MH - Genetic Markers/genetics MH - Humans MH - In Situ Hybridization, Fluorescence MH - Mice MH - Mice, Inbred Strains MH - Physical Chromosome Mapping MH - Recombination, Genetic EDAT- 1999/07/09 00:00 MHDA- 1999/07/09 00:01 CRDT- 1999/07/09 00:00 PHST- 1999/07/09 00:00 [pubmed] PHST- 1999/07/09 00:01 [medline] PHST- 1999/07/09 00:00 [entrez] AID - S0888-7543(99)95812-3 [pii] AID - 10.1006/geno.1999.5812 [doi] PST - ppublish SO - Genomics. 1999 Jul 1;59(1):1-5. doi: 10.1006/geno.1999.5812.