PMID- 10395853
OWN - NLM
STAT- MEDLINE
DCOM- 19990907
LR  - 20131121
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 180
IP  - 2
DP  - 1999 Aug
TI  - Effect of parenteral antibiotic administration on persistence of 
      vancomycin-resistant Enterococcus faecium in the mouse gastrointestinal tract.
PG  - 384-90
AB  - A mouse model of vancomycin-resistant Enterococcus faecium (VRE) intestinal 
      colonization was used to study the effect of different subcutaneous antibiotics 
      on persistence and density of VRE colonization. Gastric inoculation of a clinical 
      VanB VRE isolate, in conjunction with oral vancomycin in drinking water (250 
      microgram/mL), resulted in high-level VRE colonization (mean, 9.5 log10 cfu/g) in 
      all 169 experimental mice. After discontinuation of oral vancomycin, the level of 
      VRE in the stool specimens of mice receiving subcutaneous saline steadily 
      decreased (mean, 3.59 log10 cfu/g at day 19). Subcutaneous vancomycin, 
      clindamycin, piperacillin-tazobactam, ticarcillin-clavulanic acid, metronidazole, 
      cefotetan, ampicillin, and ampicillin-sulbactam all promoted persistent high 
      levels of stool VRE. Subcutaneous ceftriaxone, cefepime, ciprofloxacin, and 
      aztreonam promoted increased VRE density to a lesser degree or not at all. Thus, 
      in a mouse model, vancomycin and antibiotics with potent antianaerobic activity 
      promoted persistent high-density intestinal VRE colonization, whereas antibiotics 
      lacking potent antianaerobic activity did not.
FAU - Donskey, C J
AU  - Donskey CJ
AD  - Division of Infectious Diseases, Louis Stokes Cleveland Department of Veterans 
      Affairs Medical Center, Cleveland, Ohio, USA.
FAU - Hanrahan, J A
AU  - Hanrahan JA
FAU - Hutton, R A
AU  - Hutton RA
FAU - Rice, L B
AU  - Rice LB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Anti-Bacterial Agents)
RN  - 6Q205EH1VU (Vancomycin)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*administration & dosage/*pharmacology
MH  - Colony Count, Microbial
MH  - Digestive System/*microbiology
MH  - Drug Resistance, Microbial
MH  - Enterococcus faecium/*drug effects/growth & development/isolation & purification
MH  - Feces/microbiology
MH  - Female
MH  - Humans
MH  - Injections, Subcutaneous
MH  - Mice
MH  - Vancomycin/administration & dosage/*pharmacology
EDAT- 1999/07/09 10:00
MHDA- 2000/03/21 09:00
CRDT- 1999/07/09 10:00
PHST- 1999/07/09 10:00 [pubmed]
PHST- 2000/03/21 09:00 [medline]
PHST- 1999/07/09 10:00 [entrez]
AID - JID981279 [pii]
AID - 10.1086/314874 [doi]
PST - ppublish
SO  - J Infect Dis. 1999 Aug;180(2):384-90. doi: 10.1086/314874.