PMID- 10397904
OWN - NLM
STAT- MEDLINE
DCOM- 20001002
LR  - 20190910
IS  - 0021-9304 (Print)
IS  - 0021-9304 (Linking)
VI  - 44
IP  - 1
DP  - 1999 Jan
TI  - Synthesis of superporous hydrogels: hydrogels with fast swelling and 
      superabsorbent properties.
PG  - 53-62
AB  - We have been interested in the synthesis of hydrogels with fast swelling kinetics 
      and superabsorbent properties. To increase the water absorption rate, 
      interconnected pores were introduced to the hydrogels. Since the pore size in the 
      dried hydrogels is in the order of hundreds of micrometers, these hydrogels are 
      called "superporous" hydrogels. Superporous hydrogels were synthesized by 
      crosslinking polymerization of various vinyl monomers in the presence of gas 
      bubbles formed by the chemical reaction of acid and NaHCO3. The polymerization 
      process was optimized to capture the gas bubbles inside the synthesized 
      hydrogels. The use of the NaHCO3/acid system allowed easy control of timing for 
      gelation and foam formation. We found that PF127 was the best foam stabilizer for 
      most of the monomer systems used in our study. Scanning electron microscope (SEM) 
      pictures showed interconnected pores forming capillary channels. The capillary 
      channels, which were critical for fast swelling, were preserved during drying by 
      dehydrating water-swollen hydrogels with ethanol before drying. The 
      ethanol-dehydrated superporous hydrogels reached equilibrium swelling within 
      minutes. The equilibrium swelling time could be reduced to less than a minute 
      with the use of a wetting agent. In our study, water moisture was used as a 
      wetting agent since the amount of moisture content in the dried hydrogels easily 
      could be controlled. Preparation of superporous hydrogels using the right blowing 
      system, foam stabilizer, drying method, and wetting agent makes it possible to 
      reduce the swelling time to less than a minute regardless of the size of the 
      dried gels. The superporous hydrogels can be used where fast swelling and 
      superabsorbent properties are critical.
CI  - Copyright 1999 John Wiley & Sons, Inc.
FAU - Chen, J
AU  - Chen J
AD  - Purdue University, School of Pharmacy, West Lafayette, Indiana 47907-1336, USA.
FAU - Park, H
AU  - Park H
FAU - Park, K
AU  - Park K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Biomed Mater Res
JT  - Journal of biomedical materials research
JID - 0112726
RN  - 0 (Hydrogels)
RN  - 059QF0KO0R (Water)
RN  - 8MDF5V39QO (Sodium Bicarbonate)
SB  - IM
MH  - Absorption
MH  - Desiccation
MH  - Hydrogels/*chemical synthesis/*chemistry
MH  - Kinetics
MH  - Microscopy, Electron, Scanning
MH  - Sodium Bicarbonate
MH  - Structure-Activity Relationship
MH  - Water
EDAT- 1999/07/09 10:00
MHDA- 2000/10/07 11:01
CRDT- 1999/07/09 10:00
PHST- 1999/07/09 10:00 [pubmed]
PHST- 2000/10/07 11:01 [medline]
PHST- 1999/07/09 10:00 [entrez]
AID - 10.1002/(SICI)1097-4636(199901)44:1<53::AID-JBM6>3.0.CO;2-W [pii]
AID - 10.1002/(sici)1097-4636(199901)44:1<53::aid-jbm6>3.0.co;2-w [doi]
PST - ppublish
SO  - J Biomed Mater Res. 1999 Jan;44(1):53-62. doi: 
      10.1002/(sici)1097-4636(199901)44:1<53::aid-jbm6>3.0.co;2-w.