PMID- 10399792
OWN - NLM
STAT- MEDLINE
DCOM- 19990824
LR  - 20220410
IS  - 0172-8172 (Print)
IS  - 0172-8172 (Linking)
VI  - 18
IP  - 5-6
DP  - 1999
TI  - Sicca syndrome in patients with sarcoidosis.
PG  - 177-80
AB  - Out of 134, 12 sarcoidosis patients with symptoms of mucosal dryness as the first 
      clinical manifestation were identified and compared with 30 consecutive 
      unselected Sjogren's syndrome (SS) patients. Sicca manifestations were similar 
      among the two groups, while parotid gland enlargement (PGE) was more frequently 
      found in sarcoidosis patients (P < 0.05). Patients with sarcoidosis had mainly 
      pulmonary (P < 0.001) and skin involvement (P < 0.05), while SS patients 
      presented more frequently with Raynaud's phenomenon (P < 0.05). Autoantibody 
      profile was more often found in SS patients compared to sarcoidosis (P < 0.0025). 
      The histopathological findings of minor salivary gland biopsy (MSGB) revealed 
      noncaseating granulomas (NCG) in 58% of patients with sarcoidosis, while in SS, 
      MSGB showed focal sialadenitis in the majority of the patients. Transbronchial 
      lung biopsy (TBLB), which was performed in 10 sarcoidosis patients, revealed the 
      presence of NCG in all patients. In patients with sarcoidosis and sicca symptoms 
      as the presenting syndrome, PGE is a useful clinical finding. Searching for 
      pulmonary involvement is a determining factor to differentiate sarcoidosis from 
      SS. The absence of autoantibodies is another useful tool for the diagnosis of 
      sarcoidosis. Finally, MSGB is very helpful to discriminate between sarcoidosis 
      and SS and when MSGB is not specific, then TBLB is valuable to confirm the 
      diagnosis.
FAU - Drosos, A A
AU  - Drosos AA
AD  - Department of Internal Medicine, Medical School, University of Ioannina, Greece.
FAU - Voulgari, P V
AU  - Voulgari PV
FAU - Psychos, D N
AU  - Psychos DN
FAU - Tsifetaki, N
AU  - Tsifetaki N
FAU - Bai, M
AU  - Bai M
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Autoantibodies/analysis
MH  - Biomarkers/analysis
MH  - Biopsy, Needle
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parotid Gland/*pathology
MH  - Prospective Studies
MH  - Reference Values
MH  - Sarcoidosis/*diagnosis
MH  - Sensitivity and Specificity
MH  - Sjogren's Syndrome/*diagnosis
EDAT- 1999/07/10 00:00
MHDA- 1999/07/10 00:01
CRDT- 1999/07/10 00:00
PHST- 1999/07/10 00:00 [pubmed]
PHST- 1999/07/10 00:01 [medline]
PHST- 1999/07/10 00:00 [entrez]
AID - 10.1007/s002960050081 [doi]
PST - ppublish
SO  - Rheumatol Int. 1999;18(5-6):177-80. doi: 10.1007/s002960050081.