PMID- 10400816
OWN - NLM
STAT- MEDLINE
DCOM- 19990824
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 73
IP  - 8
DP  - 1999 Aug
TI  - STAT6-deficient mice exhibit normal induction of murine AIDS and expression of 
      immunoglobulin E following infection with LP-BM5 murine leukemia viruses.
PG  - 7093-5
AB  - The unique Gag polyprotein of the replication-defective virus responsible for 
      murine AIDS (MAIDS) induces B-cell activation, proliferation, and 
      differentiation, including immunoglobulin class switch-recombination to 
      immunoglobulin E (IgE). Secretion of IgE normally requires the serial induction 
      of interleukin 4 (IL-4), engagement of the IL-4 receptor, activation of signal 
      transducer and activator of transcription (STAT) 6, and induction of Iepsilon 
      germline transcripts as a prelude to switching. Remarkably, expression of IgE is 
      equivalent in normal and IL-4-deficient mice with MAIDS (Morawetz et al., J. Exp. 
      Med. 184:1651-1661, 1996). To understand this anomaly, we studied mice with a 
      null mutation of STAT6. Lymphoproliferation and immunodeficiency, the hallmarks 
      of MAIDS, developed with comparable kinetics and degree in normal and mutant 
      mice. In addition, serum IgE levels were indistinguishable in mice of either 
      genotype. We conclude that B cells from mice with MAIDS activate unique IL-4- and 
      STAT6-independent signaling pathways for B-cell activation and differentiation.
FAU - Morse, H C 3rd
AU  - Morse HC 3rd
AD  - Laboratory of Immunopathology, National Institute of Allergy and Infectious 
      Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. 
      hmorse@atlas.niaid.nih.gov
FAU - McCarty, T
AU  - McCarty T
FAU - Giese, N A
AU  - Giese NA
FAU - Taddesse-Heath, L
AU  - Taddesse-Heath L
FAU - Grusby, M J
AU  - Grusby MJ
LA  - eng
GR  - R01 AI040171/AI/NIAID NIH HHS/United States
GR  - AI40171/AI/NIAID NIH HHS/United States
GR  - N01-AI-45203/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (STAT6 Transcription Factor)
RN  - 0 (Stat6 protein, mouse)
RN  - 0 (Trans-Activators)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Immunoglobulin E/*biosynthesis
MH  - Interleukin-4/immunology
MH  - Leukemia Virus, Murine/*immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Murine Acquired Immunodeficiency Syndrome/*immunology
MH  - STAT6 Transcription Factor
MH  - Trans-Activators/genetics/*physiology
PMC - PMC112803
EDAT- 1999/07/10 10:00
MHDA- 2001/03/28 10:01
PMCR- 1999/08/01
CRDT- 1999/07/10 10:00
PHST- 1999/07/10 10:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1999/07/10 10:00 [entrez]
PHST- 1999/08/01 00:00 [pmc-release]
AID - 0336 [pii]
AID - 10.1128/JVI.73.8.7093-7095.1999 [doi]
PST - ppublish
SO  - J Virol. 1999 Aug;73(8):7093-5. doi: 10.1128/JVI.73.8.7093-7095.1999.