PMID- 10400987
OWN - NLM
STAT- MEDLINE
DCOM- 19990914
LR  - 20191210
IS  - 0964-6906 (Print)
IS  - 0964-6906 (Linking)
VI  - 8
IP  - 8
DP  - 1999 Aug
TI  - Mild impairment of learning and memory in mice overexpressing the mSim2 gene 
      located on chromosome 16: an animal model of Down's syndrome.
PG  - 1409-15
AB  - Human Sim2 is a product of one of the genes located on human chromosome 21q22 and 
      is a homolog of Drosophila single-minded ( sim ) which is a critical player in 
      midline development of the central nervous system of the fly. Since Sim2 mRNA is 
      expressed in facial, skull, palate and vertebra primordia in human and rodent 
      embryos, features that are associated with phenotypes of Down's syndrome (DS), 
      its trisomic state is suspected to contribute to the symptoms of DS. Here we 
      describe that mSim2 mRNA is expressed in hippocampus and amygdala of adult mice, 
      and that while mice overexpressing mSim2 under the control of the beta-actin 
      promoter are viable and fertile and have superficially normal skeletal, brain and 
      heart structures, they exhibit a moderate defect in context-dependent fear 
      conditioning and a mild defect in the Morris water maze test. Taken together, our 
      data show that overdosage of Sim2 may be important for the pathogenesis of Down's 
      syndrome, especially mental retardation.
FAU - Ema, M
AU  - Ema M
AD  - Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 
      980-8578, Japan,
FAU - Ikegami, S
AU  - Ikegami S
FAU - Hosoya, T
AU  - Hosoya T
FAU - Mimura, J
AU  - Mimura J
FAU - Ohtani, H
AU  - Ohtani H
FAU - Nakao, K
AU  - Nakao K
FAU - Inokuchi, K
AU  - Inokuchi K
FAU - Katsuki, M
AU  - Katsuki M
FAU - Fujii-Kuriyama, Y
AU  - Fujii-Kuriyama Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Hum Mol Genet
JT  - Human molecular genetics
JID - 9208958
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (SIM2 protein, human)
RN  - 0 (sim protein, Drosophila)
SB  - IM
MH  - Animals
MH  - Basic Helix-Loop-Helix Transcription Factors
MH  - Behavior, Animal/physiology
MH  - Chromosomes/*genetics
MH  - Chromosomes, Human, Pair 21/genetics
MH  - Conditioning, Psychological/physiology
MH  - DNA-Binding Proteins/*genetics
MH  - Disease Models, Animal
MH  - Down Syndrome/genetics
MH  - Drosophila Proteins
MH  - Fear
MH  - Gene Expression Regulation
MH  - Genotype
MH  - Humans
MH  - Learning Disabilities/genetics/*physiopathology
MH  - Maze Learning/physiology
MH  - Memory Disorders/genetics/*physiopathology
MH  - Mice
MH  - Mice, Transgenic
MH  - Motor Activity/physiology
MH  - Nuclear Proteins/*genetics
MH  - RNA, Messenger/genetics/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Swimming
MH  - Tissue Distribution
EDAT- 1999/07/13 00:00
MHDA- 1999/07/13 00:01
CRDT- 1999/07/13 00:00
PHST- 1999/07/13 00:00 [pubmed]
PHST- 1999/07/13 00:01 [medline]
PHST- 1999/07/13 00:00 [entrez]
AID - ddc165 [pii]
AID - 10.1093/hmg/8.8.1409 [doi]
PST - ppublish
SO  - Hum Mol Genet. 1999 Aug;8(8):1409-15. doi: 10.1093/hmg/8.8.1409.