PMID- 10401684
OWN - NLM
STAT- MEDLINE
DCOM- 19990901
LR  - 20190905
IS  - 0340-5761 (Print)
IS  - 0340-5761 (Linking)
VI  - 73
IP  - 3
DP  - 1999 Apr-May
TI  - Suppression of uterine decidualization as a cause of implantation failure induced 
      by triphenyltin chloride in rats.
PG  - 175-9
AB  - In our previous study, triphenyltin chloride (TPTC1) was found to induce 
      implantation failure, as preimplantation embryonic loss, in rats. In this study, 
      the effects of TPTC1 on the uterine function, as a cause of implantation failure, 
      were determined using pseudopregnant rats. Female rats were given TPTC1 by 
      gastric intubation at 3.1, 4.7, and 6.3 mg/kg on pseudopregnant day (PPD) 0 to 
      PPD 3 and the decidual cell response was induced on PPD 4. The uterine weight on 
      PPD 9 served as an index of uterine decidualization. A significant decrease in 
      the uterine weight, which indicates suppression of the uterine decidualization, 
      was detected at 4.7 and 6.3 mg/kg. In our previous study, these doses induced a 
      significant increase in implantation failure in female rats given TPTC1 on 
      gestational day (GD) 0 to 3. The ovarian weight and number of corpora lutea in 
      the TPTC1-treated groups were comparable to that of the controls. A significant 
      decrease in serum progesterone levels after administration of TPTC1 was found at 
      4.7 and 6.3 mg/kg. These findings suggest that implantation failure due to TPTC1 
      may be mediated via the suppression of uterine decidualization and correlated 
      with the reduction in serum progesterone levels.
FAU - Ema, M
AU  - Ema M
AD  - National Institute of Health Sciences, Osaka Branch, Japan. ema@nihs.go.jp
FAU - Miyawaki, E
AU  - Miyawaki E
FAU - Kawashima, K
AU  - Kawashima K
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Arch Toxicol
JT  - Archives of toxicology
JID - 0417615
RN  - 0 (Organotin Compounds)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 95T92AGN0V (triphenyltin)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - Corpus Luteum/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Eating/drug effects
MH  - Embryo Implantation/*drug effects
MH  - Female
MH  - Organ Size/drug effects
MH  - Organotin Compounds/*toxicity
MH  - Ovary/drug effects/enzymology
MH  - Progesterone/blood/*metabolism
MH  - Pseudopregnancy
MH  - Rats
MH  - Rats, Wistar
MH  - Uterus/*drug effects
EDAT- 1999/07/13 00:00
MHDA- 1999/07/13 00:01
CRDT- 1999/07/13 00:00
PHST- 1999/07/13 00:00 [pubmed]
PHST- 1999/07/13 00:01 [medline]
PHST- 1999/07/13 00:00 [entrez]
AID - 10.1007/s002040050603 [doi]
PST - ppublish
SO  - Arch Toxicol. 1999 Apr-May;73(3):175-9. doi: 10.1007/s002040050603.