PMID- 10402511
OWN - NLM
STAT- MEDLINE
DCOM- 19991101
LR  - 20190905
IS  - 0148-7299 (Print)
IS  - 0148-7299 (Linking)
VI  - 88
IP  - 4
DP  - 1999 Aug 20
TI  - HLA and schizophrenia: refutation of reported associations with A9 (A23/A24), 
      DR4, and DQbeta1*0602.
PG  - 416-21
AB  - The aim of this study was to test previous hypotheses of association between 
      schizophrenia and human leukocyte antigen (HLA) specificities A9 (A23/24), DR4, 
      and allele DQbeta1*0602. Using sequence-specific oligonucleotide probes, 256 
      familial schizophrenic patients and 261 unrelated controls were genotyped at 
      polymorphisms for HLA-A, DRbeta1, and DQbeta1 loci. No significant (p < 0.05) 
      differences in the allele frequencies between schizophrenics and controls were 
      found, either when examining the sample as a whole or when subdivided by clinical 
      subtype or gender. The present data do not support association between these HLA 
      specificities and schizophrenia, and our review of previous studies suggests that 
      reported associations may well be false positive results.
CI  - Copyright 1999 Wiley-Liss, Inc.
FAU - Gibson, S
AU  - Gibson S
AD  - Department of Psychiatry and Genetics, Trinity College, Dublin, Ireland.
FAU - Hawi, Z
AU  - Hawi Z
FAU - Straub, R E
AU  - Straub RE
FAU - Walsh, D
AU  - Walsh D
FAU - Kendler, K S
AU  - Kendler KS
FAU - Gill, M
AU  - Gill M
LA  - eng
GR  - MH41953/MH/NIMH NIH HHS/United States
GR  - MH46390/MH/NIMH NIH HHS/United States
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Med Genet
JT  - American journal of medical genetics
JID - 7708900
RN  - 0 (Genetic Markers)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A9 antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR4 Antigen)
SB  - IM
MH  - Case-Control Studies
MH  - Genetic Markers
MH  - Genotype
MH  - HLA-A Antigens/*genetics
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR4 Antigen/*genetics
MH  - Humans
MH  - Phenotype
MH  - Schizophrenia/*genetics
EDAT- 1999/07/14 00:00
MHDA- 1999/07/14 00:01
CRDT- 1999/07/14 00:00
PHST- 1999/07/14 00:00 [pubmed]
PHST- 1999/07/14 00:01 [medline]
PHST- 1999/07/14 00:00 [entrez]
AID - 10.1002/(SICI)1096-8628(19990820)88:4<416::AID-AJMG21>3.0.CO;2-S [pii]
AID - 10.1002/(sici)1096-8628(19990820)88:4<416::aid-ajmg21>3.0.co;2-s [doi]
PST - ppublish
SO  - Am J Med Genet. 1999 Aug 20;88(4):416-21. doi: 
      10.1002/(sici)1096-8628(19990820)88:4<416::aid-ajmg21>3.0.co;2-s.