PMID- 10403227
OWN - NLM
STAT- MEDLINE
DCOM- 19990719
LR  - 20190813
IS  - 0013-9580 (Print)
IS  - 0013-9580 (Linking)
VI  - 40
IP  - 7
DP  - 1999 Jul
TI  - Nonconvulsive status epilepticus in childhood localization-related epilepsy.
PG  - 1003-10
AB  - PURPOSE: To report on three children with localization-related epilepsy who 
      exhibited minor seizures (atypical absences, brief atonic, and myoclonic) and 
      nonconvulsive status epilepticus (NCSE) consisting of these minor seizures, and 
      to elucidate their significance. METHODS: We studied the electroclinical 
      characteristics of these children. Ictal electroencephalograms (EEGs) of NCSE 
      were evaluated by using simultaneous video-EEG-electromyogram (EMG) polygraphic 
      recordings. RESULTS: All patients began to have partial seizures between the ages 
      of 6 months and 2 years 7 months, with minor seizures appearing later, between 
      the ages of 1 year 11 months and 6 years 6 months. These minor seizures evolved 
      into NCSE. Complex partial seizures remained after suppression of the minor 
      seizures. Interictal EEGs taken when the minor seizures appeared showed excessive 
      diffuse epileptic discharges in addition to multifocal spike-waves. Before and 
      after suppression of the minor seizures, focal epileptic discharges predominated 
      on the EEGs. On ictal EEGs of brief atonic and myoclonic seizures, diffuse 
      spike-wave and polyspike-wave bursts were detected. Ictal EEGs of the atypical 
      absences revealed diffuse spike-wave bursts mixed with irregular high-voltage 
      slow waves, often interspersed with brief atonic and myoclonic seizures. When 
      atypical absences lasted for a long time, patients manifested NCSE. Polytherapy 
      might be related to the occurrence of minor seizures and NCSE, because all 
      patients were treated with polytherapy at their appearance, and simplification of 
      antiepileptic drug (AED) therapy seemed to be effective. CONCLUSIONS: We 
      concluded that this NCSE is a type of atypical absence status which is an 
      age-dependent, transient, electroclinical condition. The mechanism of occurrence 
      of these minor seizures might be related to secondary bilateral synchrony.
FAU - Ohtsuka, Y
AU  - Ohtsuka Y
AD  - Department of Child Neurology, Okayama University Medical School, Japan.
FAU - Sato, M
AU  - Sato M
FAU - Oka, E
AU  - Oka E
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Comorbidity
MH  - Diagnosis, Differential
MH  - Electroencephalography/*statistics & numerical data
MH  - Electromyography
MH  - Epilepsies, Myoclonic/diagnosis/epidemiology
MH  - Epilepsies, Partial/*diagnosis/epidemiology
MH  - Epilepsy, Absence/diagnosis/epidemiology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Monitoring, Physiologic
MH  - Seizures/diagnosis/epidemiology
MH  - Status Epilepticus/*diagnosis/epidemiology
EDAT- 1999/07/14 00:00
MHDA- 1999/07/14 00:01
CRDT- 1999/07/14 00:00
PHST- 1999/07/14 00:00 [pubmed]
PHST- 1999/07/14 00:01 [medline]
PHST- 1999/07/14 00:00 [entrez]
AID - 10.1111/j.1528-1157.1999.tb00810.x [doi]
PST - ppublish
SO  - Epilepsia. 1999 Jul;40(7):1003-10. doi: 10.1111/j.1528-1157.1999.tb00810.x.