PMID- 10403830
OWN - NLM
STAT- MEDLINE
DCOM- 19990816
LR  - 20071115
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 260
IP  - 3
DP  - 1999 Jul 14
TI  - Dynamic expression pattern of Ca(2+)/calmodulin-dependent protein kinase II gene 
      in the central nervous system of Drosophila throughout development.
PG  - 707-11
AB  - Calcium/calmodulin-dependent protein kinase II (CaM KII) is thought to be 
      involved in the majority of the neuronal functions mediated by intracellular free 
      Ca(2+), and has been implicated in long-term potentiation, learning, and memory. 
      In this work, we have examined in detail the RNA expression pattern for the 
      Drosophila CaM KII gene by in situ hybridization, during embryonic, larval, 
      pupal, and adult stages. Our results indicate that expression of CaM KII was 
      homogeneous in early embryos, but that during development the gene transcription 
      rapidly became restricted to neuroblasts and their progeny in the nervous system. 
      This predominant expression in the nervous system is maintained during late 
      embryogenesis and post-embryonic development. A signal compartmentalization 
      appeared in the larval central nervous system, where the CaM KII expression 
      became progressively concentrated in the anterior ganglia. In the adult brain, a 
      specific expression was more abundant in a subset of neurons around the central 
      brain, particularly the mushroom bodies and the central complex, structures that 
      play an important role in learning and memory.
CI  - Copyright 1999 Academic Press.
FAU - Rachidi, M
AU  - Rachidi M
AD  - Department of Molecular Biology, Pasteur Institute, 25 rue du Docteur Roux, 
      Paris, 75015, France.
FAU - Lopes, C
AU  - Lopes C
FAU - Takamatsu, Y
AU  - Takamatsu Y
FAU - Ohsako, S
AU  - Ohsako S
FAU - Benichou, J C
AU  - Benichou JC
FAU - Delabar, J M
AU  - Delabar JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
SB  - IM
MH  - Animals
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2
MH  - Calcium-Calmodulin-Dependent Protein Kinases/*genetics
MH  - Cell Lineage
MH  - Central Nervous System/cytology/embryology/enzymology/growth & development
MH  - Drosophila melanogaster/embryology/*enzymology/genetics/*growth & development
MH  - Embryo, Nonmammalian/cytology/enzymology
MH  - Embryonic Development
MH  - Ganglia, Invertebrate/cytology/enzymology
MH  - *Gene Expression Regulation, Developmental
MH  - *Genes, Insect
MH  - In Situ Hybridization
MH  - Larva/cytology/enzymology/growth & development
MH  - Neuronal Plasticity
MH  - Neurons/cytology/enzymology
MH  - Pupa/cytology/enzymology/growth & development
MH  - RNA, Messenger/genetics/metabolism
MH  - Time Factors
EDAT- 1999/07/15 00:00
MHDA- 1999/07/15 00:01
CRDT- 1999/07/15 00:00
PHST- 1999/07/15 00:00 [pubmed]
PHST- 1999/07/15 00:01 [medline]
PHST- 1999/07/15 00:00 [entrez]
AID - S0006-291X(99)90868-9 [pii]
AID - 10.1006/bbrc.1999.0868 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1999 Jul 14;260(3):707-11. doi: 
      10.1006/bbrc.1999.0868.