PMID- 10404078
OWN - NLM
STAT- MEDLINE
DCOM- 19990805
LR  - 20190708
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 82
IP  - 4
DP  - 1999 Aug 12
TI  - Synovial sarcoma specific translocation associated with both epithelial and 
      spindle cell components.
PG  - 605-8
AB  - The biphasic subtype of synovial sarcoma consists of both epithelial and spindle 
      cell components. To address the relationship between the different cellular 
      components found in synovial sarcoma, we deduced the presence of the synovial 
      sarcoma-specific der(X)t(X;18)(p11.2;q11.2), and involvement of the SSX1 gene in 
      both the epithelial/glandular and spindle cell components of 3 biphasic synovial 
      sarcomas with wide ranging proportions of each of the 2 elements. This has been 
      achieved using a 2-color fluorescence in situ hybridization (FISH) methodology 
      that we had developed recently for analysis paraffin-embedded material. The 
      presence of the rearrangement could be deduced in histologically defined regions 
      and the results showed clearly that the rearrangement was present in both 
      cellular components. This finding provides direct genetic evidence for biphasic 
      synovial sarcomas being clonal and truly biphasic.
CI  - Copyright 1999 Wiley-Liss, Inc.
FAU - Birdsall, S
AU  - Birdsall S
AD  - Molecular Cytogenetics, Section of Molecular Carcinogenesis, Institute of Cancer 
      Research, Sutton, UK.
FAU - Osin, P
AU  - Osin P
FAU - Lu, Y J
AU  - Lu YJ
FAU - Fisher, C
AU  - Fisher C
FAU - Shipley, J
AU  - Shipley J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Repressor Proteins)
RN  - 164289-47-8 (synovial sarcoma X breakpoint proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Child, Preschool
MH  - Chromosomes, Human, Pair 18/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/genetics
MH  - Repressor Proteins/genetics
MH  - Sarcoma, Synovial/*genetics/pathology
MH  - Translocation, Genetic/*genetics
MH  - X Chromosome/*genetics
EDAT- 1999/07/15 00:00
MHDA- 1999/07/15 00:01
CRDT- 1999/07/15 00:00
PHST- 1999/07/15 00:00 [pubmed]
PHST- 1999/07/15 00:01 [medline]
PHST- 1999/07/15 00:00 [entrez]
AID - 10.1002/(SICI)1097-0215(19990812)82:4<605::AID-IJC22>3.0.CO;2-H [pii]
AID - 10.1002/(sici)1097-0215(19990812)82:4<605::aid-ijc22>3.0.co;2-h [doi]
PST - ppublish
SO  - Int J Cancer. 1999 Aug 12;82(4):605-8. doi: 
      10.1002/(sici)1097-0215(19990812)82:4<605::aid-ijc22>3.0.co;2-h.