PMID- 10404984
OWN - NLM
STAT- MEDLINE
DCOM- 19990811
LR  - 20220408
IS  - 0003-9942 (Print)
IS  - 0003-9942 (Linking)
VI  - 56
IP  - 7
DP  - 1999 Jul
TI  - Posterior cerebral artery territory infarcts in the New England Medical Center 
      Posterior Circulation Registry.
PG  - 824-32
AB  - BACKGROUND: Infarcts in the territory of the posterior cerebral arteries (PCAs) 
      are common. Although associated clinical symptoms and signs are known, the 
      mechanisms of stroke and the anatomical distribution of PCA territory lesions 
      caused by the various stroke mechanisms are less well defined. Published reports 
      have selected only special subgroups of patients. PATIENTS AND METHODS: We 
      studied stroke mechanisms, infarct distribution, and clinical findings among 79 
      patients in the New England Medical Center Posterior Circulation Registry in whom 
      brain imaging scans showed infarcts that involved 1 or more cortical territories 
      of the PCA. RESULTS: Forty-eight patients (61%) had infarcts limited to the PCA 
      territory (pure PCA), while 31 (39%) also had infarcts in other territories 
      (PCA+). Infarcts were in the cortical territory of the PCA in 47 patients (59%) 
      and were cortical and deep in 32 (41%). Infarcts that were cortical and deep were 
      more common in PCA+ lesions. Stroke mechanisms were embolism of cardiac origin 
      (32 [41%]), proximal arterial disease (25[32%]), cryptogenic embolism (8[10%]), 
      intrinsic PCA disease (7[9%]), vasoconstriction (4[5%]), and coagulopathy 
      (3[4%]). Patients with cardiogenic embolism and intrinsic PCA disease often had 
      pure PCA territory infarcts, while patients with proximal arterial disease more 
      often had PCA+ infarcts. Visual abnormalities were present in 66 patients (84%). 
      Motor weakness, cognitive and behavioral abnormalities, and ataxia were found in 
      20 patients (25%); only 12 (15%) had sensory signs. CONCLUSIONS: The great 
      majority of pure PCA and PCA+ territory infarcts are caused by cardiac or 
      intra-arterial embolism. Intrinsic PCA disease, vasoconstriction, and 
      coagulopathy are less common causes of infarction.
FAU - Yamamoto, Y
AU  - Yamamoto Y
AD  - Department of Neurology, Second Red Cross Hospital, Kyoto, Japan.
FAU - Georgiadis, A L
AU  - Georgiadis AL
FAU - Chang, H M
AU  - Chang HM
FAU - Caplan, L R
AU  - Caplan LR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Neurol
JT  - Archives of neurology
JID - 0372436
SB  - IM
MH  - Academic Medical Centers
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain/*blood supply
MH  - Cerebral Arterial Diseases/*complications
MH  - Cerebral Infarction/*etiology
MH  - Female
MH  - Heart Diseases/complications
MH  - Humans
MH  - Intracranial Embolism and Thrombosis/complications
MH  - Male
MH  - Middle Aged
MH  - New England
MH  - Prospective Studies
MH  - *Registries
MH  - Risk Factors
EDAT- 1999/07/15 00:00
MHDA- 1999/07/15 00:01
CRDT- 1999/07/15 00:00
PHST- 1999/07/15 00:00 [pubmed]
PHST- 1999/07/15 00:01 [medline]
PHST- 1999/07/15 00:00 [entrez]
AID - 10.1001/archneur.56.7.824 [doi]
PST - ppublish
SO  - Arch Neurol. 1999 Jul;56(7):824-32. doi: 10.1001/archneur.56.7.824.