PMID- 10405024
OWN - NLM
STAT- MEDLINE
DCOM- 19990908
LR  - 20190910
IS  - 0300-4864 (Print)
IS  - 0300-4864 (Linking)
VI  - 27
IP  - 8
DP  - 1998 Aug
TI  - Induction of beta-family chemokines mRNA in human embryonic astrocytes by 
      inflammatory cytokines and measles virus protein.
PG  - 575-80
AB  - The cellular infiltration found during CNS inflammation consists of monocytes and 
      activated T cells, suggesting the presence of cell-specific chemotactic signals 
      during inflammatory responses. Astrocyte chemokine expression might contribute to 
      site-specific leukocyte infiltration within the CNS. To investigate the factors 
      that regulate astrocyte chemokine expression, we examined the ability of human 
      fetal astrocytes to induce beta-family chemokine mRNA. Astrocyte-derived monocyte 
      chemoattractant protein-1 (MCP-1), RANTES, macrophage inflammatory protein-1alpha 
      (MIP-1alpha), and MIP-1beta mRNA were easily induced by lipopolysaccharide and/or 
      the proinflammatory cytokines (IFN-gamma and/or TNF-alpha), respectively. 
      Addition of both IFN-gamma and TNF-alpha together did not lead to an additive 
      effect but resulted in the inhibition of MCP-1 and MIP-1beta mRNA expression, 
      indicating that interaction between chemokines and cytokines may play a key role 
      in regulating the local immune response of resident and infiltrating cells at the 
      site of lesion. Interestingly, ultraviolet light-inactivated measles virus, but 
      not cytomegalovirus, strongly induced expression of MCP-1, RANTES, MIP-1alpha, 
      and MIP-1beta mRNA in human embryonic astrocytes, especially MCP-1 and MIP-1beta. 
      An association occurs between the beta-family chemokine expression in astrocytes 
      and inflammatory factors/virus, suggesting a possible role for beta-family 
      chemokines in the pathogenesis of CNS inflammatory disease.
FAU - Xiao, B G
AU  - Xiao BG
AD  - Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, 
      Huddinge University Hospital, Stockholm, Sweden.
FAU - Mousa, A
AU  - Mousa A
FAU - Kivisakk, P
AU  - Kivisakk P
FAU - Seiger, A
AU  - Seiger A
FAU - Bakhiet, M
AU  - Bakhiet M
FAU - Link, H
AU  - Link H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurocytol
JT  - Journal of neurocytology
JID - 0364620
RN  - 0 (Chemokines, CC)
RN  - 0 (Cytokines)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Viral Proteins)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Astrocytes/*drug effects/*metabolism
MH  - Cells, Cultured
MH  - Chemokines, CC/*biosynthesis
MH  - Cytokines/*pharmacology
MH  - Cytomegalovirus/immunology
MH  - Dose-Response Relationship, Drug
MH  - Embryo, Mammalian
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Inflammation/metabolism
MH  - Interferon-gamma/pharmacology
MH  - Lipopolysaccharides/pharmacology
MH  - Measles virus/immunology
MH  - RNA, Messenger/biosynthesis
MH  - Tumor Necrosis Factor-alpha/pharmacology
MH  - Viral Proteins/*pharmacology
EDAT- 1999/07/15 00:00
MHDA- 1999/07/15 00:01
CRDT- 1999/07/15 00:00
PHST- 1999/07/15 00:00 [pubmed]
PHST- 1999/07/15 00:01 [medline]
PHST- 1999/07/15 00:00 [entrez]
AID - 10.1023/a:1006918110952 [doi]
PST - ppublish
SO  - J Neurocytol. 1998 Aug;27(8):575-80. doi: 10.1023/a:1006918110952.