PMID- 10406076
OWN - NLM
STAT- MEDLINE
DCOM- 19990826
LR  - 20061115
IS  - 0734-8630 (Print)
IS  - 0734-8630 (Linking)
VI  - 17
IP  - 1
DP  - 1999
TI  - Expression of 11 beta-hydroxysteroid dehydrogenase in early pregnancy: 
      implications in human trophoblast-endometrial interactions.
PG  - 53-61
AB  - Glucocorticoid hormone action in target tissues is modulated by 11 
      beta-hydroxysteroid dehydrogenase (11 beta-HSD), which interconverts active 
      cortisol and corticosterone and their inert 11-keto metabolites, cortisone and 
      11-dehydrocorticosterone. Two different 11 beta-HSD isoforms exist: a 
      low-affinity NADP-dependent dehydrogenase/oxoreductase (11 beta-HSD1) and a 
      high-affinity NAD-dependent dehydrogenase (11 beta-HSD2). This brief review 
      describes the expression and distribution of 11 beta-HSD isoforms in human 
      placenta. In particular, it discusses the results of studies dealing with the 
      expression of 11 beta-HSD activity in experimental models representative of the 
      fetomaternal interface in the early gestation. The findings have implications in 
      terms of protection of the fetus against corticosteroid toxicity and modulation 
      of active glucocorticoid levels and their biological effects in early pregnancy.
FAU - Arcuri, F
AU  - Arcuri F
AD  - Institute of Pathological Anatomy and Histology, University of Siena, Italy.
FAU - Sestini, S
AU  - Sestini S
FAU - Cintorino, M
AU  - Cintorino M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Semin Reprod Endocrinol
JT  - Seminars in reproductive endocrinology
JID - 8308354
RN  - 0 (Isoenzymes)
RN  - EC 1.1.- (Hydroxysteroid Dehydrogenases)
RN  - EC 1.1.1.146 (11-beta-Hydroxysteroid Dehydrogenases)
SB  - IM
MH  - 11-beta-Hydroxysteroid Dehydrogenases
MH  - Cells, Cultured
MH  - Endometrium/enzymology/*physiology
MH  - Female
MH  - Humans
MH  - Hydroxysteroid Dehydrogenases/analysis/*physiology
MH  - Isoenzymes/analysis/*physiology
MH  - Placenta/*enzymology
MH  - Pregnancy
MH  - Tissue Distribution
MH  - Trophoblasts/enzymology/*physiology
RF  - 63
EDAT- 1999/07/16 00:00
MHDA- 1999/07/16 00:01
CRDT- 1999/07/16 00:00
PHST- 1999/07/16 00:00 [pubmed]
PHST- 1999/07/16 00:01 [medline]
PHST- 1999/07/16 00:00 [entrez]
AID - 10.1055/s-2007-1016212 [doi]
PST - ppublish
SO  - Semin Reprod Endocrinol. 1999;17(1):53-61. doi: 10.1055/s-2007-1016212.