PMID- 10407469
OWN - NLM
STAT- MEDLINE
DCOM- 19990902
LR  - 20081121
IS  - 0002-9645 (Print)
IS  - 0002-9645 (Linking)
VI  - 60
IP  - 7
DP  - 1999 Jul
TI  - Safety and efficacy of vaccination of pregnant gilts against porcine reproductive 
      and respiratory syndrome.
PG  - 796-801
AB  - OBJECTIVE: To determine the safety and efficacy of vaccination of pregnant gilts 
      with an attenuated strain of porcine reproductive and respiratory syndrome virus 
      (PRRSV). ANIMALS: 16 pregnant gilts. PROCEDURE: Pregnant gilts free of antibodies 
      for PRRSV were assigned (4 gilts/group) to the following groups: group I, 
      untreated controls; group II, vaccinated on day 60 of gestation; group III, 
      vaccinated on day 60 of gestation and exposed to virulent PRRSV on day 90 of 
      gestation; and group IV, exposed to virulent PRRSV on day 90 of gestation. Safety 
      and efficacy of vaccination was evaluated by group comparisons of prenatal and 
      postnatal survival of fetuses and pigs, respectively, and by the condition and 
      rate of weight gain of liveborn pigs. RESULTS: Collective (prenatal and 
      postnatal) death losses up to day 15 after farrowing (conclusion of study) were 
      similar for groups I (7/47, 14.9%) and II (7/44, 16.9%) but were greater for 
      group III (18/49, 36.7%) and were greater still for group IV (23/37, 62.2%). Mean 
      body weight 15 days after farrowing was greatest for pigs in litters of group I 
      (4.46 kg) and progressively less for the other groups (3.87, 3.76, and 2.18 kg 
      for groups II, III, and IV, respectively). CONCLUSIONS: Using these conditions, 
      vaccination of gilts during midgestation appeared to be safe. However, it 
      provided only partial protection against subsequent exposure to virulent virus. 
      CLINICAL RELEVANCE: Attenuated-PRRSV vaccines may have to be administered to 
      naive gilts > 30 days before conception to provide maximum protection throughout 
      gestation.
FAU - Mengeling, W L
AU  - Mengeling WL
AD  - Virology Swine Research Unit, National Animal Disease Center, USDA, Agricultural 
      Research Service, Ames, IA 50010, USA.
FAU - Lager, K M
AU  - Lager KM
FAU - Vorwald, A C
AU  - Vorwald AC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Vet Res
JT  - American journal of veterinary research
JID - 0375011
RN  - 0 (Antibodies, Viral)
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Antibodies, Viral/blood
MH  - Birth Weight
MH  - Female
MH  - Fetus/physiopathology
MH  - Fluorescent Antibody Technique, Indirect/veterinary
MH  - Immunization/standards/*veterinary
MH  - Neutralization Tests/veterinary
MH  - Palatine Tonsil/virology
MH  - Polymerase Chain Reaction/veterinary
MH  - Polymorphism, Restriction Fragment Length
MH  - Porcine Reproductive and Respiratory Syndrome/*prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/*pathogenicity
MH  - Pregnancy
MH  - Reproduction/physiology
MH  - Respiratory Tract Diseases/veterinary
MH  - *Swine
MH  - Vaccines, Attenuated/*standards
MH  - Viral Vaccines/*standards
EDAT- 1999/07/17 00:00
MHDA- 1999/07/17 00:01
CRDT- 1999/07/17 00:00
PHST- 1999/07/17 00:00 [pubmed]
PHST- 1999/07/17 00:01 [medline]
PHST- 1999/07/17 00:00 [entrez]
PST - ppublish
SO  - Am J Vet Res. 1999 Jul;60(7):796-801.