PMID- 10408803
OWN - NLM
STAT- MEDLINE
DCOM- 19990831
LR  - 20190905
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 60
IP  - 6
DP  - 1999 Jun
TI  - Matching for HLA DPA1 and DPB1 alleles in unrelated bone marrow transplantation.
PG  - 532-8
AB  - The impact of donor-recipient DPA1 and DPB1 matching was examined in 122 
      unrelated bone marrow transplant pairs. All pairs were serologically matched at 
      the time of transplantation for HLA class I and II and a majority also DRB1 
      allele matched. Retrospective A, B, C, DRB1, DQA1, DQB1 in addition to DPA1 and 
      DPB1 allele matching was performed by molecular techniques. The percentage of 
      pairs that were allele matched was as follows; HLA-A = 91% (n = 80), HLA-B = 94% 
      (n = 80), HLA-C = 78% (n = 80), HLA-DRB1 = 96% (n = 122), HLA-DQA1 = 99% (n = 
      80), HLA-DQB1 = 92% (n = 122). 92 recipient/donor pairs with informative clinical 
      data were available for analysis. DPA1 identity (no incompatibility in either 
      direction) was observed in 57% and DPA1 compatibility in 76% of pairs with no 
      apparent beneficial effect of matching on patient survival or Graft Versus Host 
      Disease (GVHD). DPB1 identity was observed in 11% and compatibility in 27% of 
      pairs. A significant improvement in patient survival was observed in DPB1 matched 
      compared to one DPB1 mismatch (p < 0.01) and combined one and two DPB1 mismatched 
      transplants (p = 0.03). This beneficial effect remained when allele mismatches at 
      HLA-A, B, C, DRB1, DQA1, DQB1 were excluded (p = 0.05, p = 0.03, respectively). 
      There was a significant association of increased frequency of severe GVHD (grades 
      III-IV) compared to mild GVHD (grades I-II) with DPB1 mismatched transplants 
      compared to DPB1 matched transplants (p = 0.04). In DPB1 mismatched transplants 
      an association between patient survival and matching for individual DPB1 
      polymorphic regions was not observed; however in the HLA-A, B, DRB1, DQA1, DQB1 
      allele matched transplants a non significant increase in the frequency of Grade 
      IV GVHD was observed in recipients who were negative compared to those who were 
      positive for DPB1 alleles coding for glutamic acid at position 69.
FAU - Varney, M D
AU  - Varney MD
AD  - Department of Pathology, Royal Melbourne Hospital,Parkville, Vic, Australia.
FAU - Lester, S
AU  - Lester S
FAU - McCluskey, J
AU  - McCluskey J
FAU - Gao, X
AU  - Gao X
FAU - Tait, B D
AU  - Tait BD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP alpha-Chains)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPA1 antigen)
RN  - 0 (HLA-DPB1 antigen)
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Bone Marrow Transplantation/*immunology
MH  - Child
MH  - Follow-Up Studies
MH  - Graft Survival
MH  - Graft vs Host Disease
MH  - HLA-DP Antigens/*genetics
MH  - HLA-DP alpha-Chains
MH  - HLA-DP beta-Chains
MH  - Histocompatibility Testing
MH  - Humans
MH  - Prospective Studies
MH  - Retrospective Studies
EDAT- 1999/07/17 00:00
MHDA- 1999/07/17 00:01
CRDT- 1999/07/17 00:00
PHST- 1999/07/17 00:00 [pubmed]
PHST- 1999/07/17 00:01 [medline]
PHST- 1999/07/17 00:00 [entrez]
AID - S0198-8859(99)00004-X [pii]
AID - 10.1016/s0198-8859(99)00004-x [doi]
PST - ppublish
SO  - Hum Immunol. 1999 Jun;60(6):532-8. doi: 10.1016/s0198-8859(99)00004-x.